A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552910" target="_blank" >RIV/68378041:_____/21:00552910 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/21:10435160 RIV/00179906:_____/21:10435160

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11239-021-02462-y" target="_blank" >https://link.springer.com/article/10.1007/s11239-021-02462-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11239-021-02462-y" target="_blank" >10.1007/s11239-021-02462-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy

Popis výsledku v původním jazyce

Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs). These medications are supposed to have more predictable pharmacokinetics with fewer severe haemorrhagic adverse events in comparison with standard warfarin therapy. However, in the last few years, an increasing number of case reports have been published of haemorrhage into the central nervous system. We present a case of non-traumatic spinal epidural hematoma in the lumbar region in a patient on chronic apixaban therapy. To the best of our knowledge, it is the first described SSEH in the lumbar region associated with apixaban therapy.

Název v anglickém jazyce

A rare case of non-traumatic spinal epidural hematoma in lumbar region associated with apixaban therapy

Popis výsledku anglicky

Spontaneous spinal epidural hematoma (SSEH) is a very rare clinical entity with potential diagnostic difficulties and which can result in severe neurological deficit. The etiology of this rare condition is largely not known, but with potential predisposition in patients on anticoagulation medication. This includes the novel anticoagulants with direct inhibition of the factor Xa mechanism (DOACs). These medications are supposed to have more predictable pharmacokinetics with fewer severe haemorrhagic adverse events in comparison with standard warfarin therapy. However, in the last few years, an increasing number of case reports have been published of haemorrhage into the central nervous system. We present a case of non-traumatic spinal epidural hematoma in the lumbar region in a patient on chronic apixaban therapy. To the best of our knowledge, it is the first described SSEH in the lumbar region associated with apixaban therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Thrombosis and Thrombolysis

ISSN

0929-5305

e-ISSN

1573-742X

Svazek periodika

52

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

1215-1219

Kód UT WoS článku

000648020700001

EID výsledku v databázi Scopus

2-s2.0-85105358929