Frequency of Leiden Mutation in Newborns with Birth Weight below 1500 g

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00567282" target="_blank" >RIV/68378041:_____/22:00567282 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12110/22:43904496 RIV/71226401:_____/22:N0100653

Výsledek na webu

<a href="https://www.mdpi.com/2227-9032/10/5/865" target="_blank" >https://www.mdpi.com/2227-9032/10/5/865</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/healthcare10050865" target="_blank" >10.3390/healthcare10050865</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Frequency of Leiden Mutation in Newborns with Birth Weight below 1500 g

Popis výsledku v původním jazyce

It has been hypothesized that fetal prematurity or Intrauterine Growth Restriction (IUGR) could be related to the presence of factor V of Leiden mutation. This mutation is associated with a higher incidence of pregnancy difficulties that can result in preterm birth. The frequency of Leiden mutation was investigated in the group of newborns with a low birth weight below 1500 g over a six-year period from 2015 to 2020. During this period, 339 newborns were tested, of which 42 newborns with V Leiden mutation (12.4%) were detected. The average of its occurrence frequency in the Czech population was determined as 5.0% based on published studies. In our research, the occurrence of the V Leiden mutation was found significantly higher in newborns under 1500 g. At the same time, we did not demonstrate an increased frequency of births at lower gestational weeks, lower birth weight, or an association with sex in newborns with a positive diagnosis of the Leiden V factor.

Název v anglickém jazyce

Frequency of Leiden Mutation in Newborns with Birth Weight below 1500 g

Popis výsledku anglicky

It has been hypothesized that fetal prematurity or Intrauterine Growth Restriction (IUGR) could be related to the presence of factor V of Leiden mutation. This mutation is associated with a higher incidence of pregnancy difficulties that can result in preterm birth. The frequency of Leiden mutation was investigated in the group of newborns with a low birth weight below 1500 g over a six-year period from 2015 to 2020. During this period, 339 newborns were tested, of which 42 newborns with V Leiden mutation (12.4%) were detected. The average of its occurrence frequency in the Czech population was determined as 5.0% based on published studies. In our research, the occurrence of the V Leiden mutation was found significantly higher in newborns under 1500 g. At the same time, we did not demonstrate an increased frequency of births at lower gestational weeks, lower birth weight, or an association with sex in newborns with a positive diagnosis of the Leiden V factor.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment HAIE</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

HEALTHCARE-BASEL

ISSN

2227-9032

e-ISSN

2227-9032

Svazek periodika

10

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

865

Kód UT WoS článku

000801241400001

EID výsledku v databázi Scopus

2-s2.0-85130118985