The Role of miR-20 in Health and Disease of the Central Nervous System

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00568840" target="_blank" >RIV/68378041:_____/22:00568840 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10443812

Výsledek na webu

<a href="https://www.mdpi.com/2073-4409/11/9/1525" target="_blank" >https://www.mdpi.com/2073-4409/11/9/1525</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells11091525" target="_blank" >10.3390/cells11091525</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Role of miR-20 in Health and Disease of the Central Nervous System

Popis výsledku v původním jazyce

Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and traditional therapeutic methods lack a molecular approach either to prevent acute phase or secondary damage, or to support restorative mechanisms in the nervous tissue. microRNAs (miRNAs) are endogenous, non-coding RNA molecules that have recently been discovered as fundamental and post-transcriptional regulators of gene expression. The capacity of microRNAs to regulate the cell state and function through post-transcriptionally silencing hundreds of genes are being acknowledged as an important factor in the pathophysiology of both acute and chronic CNS injuries. In this study, we have summarized the knowledge concerning the pathophysiology of several neurological disorders, and the role of most canonical miRNAs in their development. We have focused on the miR-20, the miR-17 similar to 92 family to which miR-20 belongs, and their function in the normal development and disease of the CNS.

Název v anglickém jazyce

The Role of miR-20 in Health and Disease of the Central Nervous System

Popis výsledku anglicky

Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and traditional therapeutic methods lack a molecular approach either to prevent acute phase or secondary damage, or to support restorative mechanisms in the nervous tissue. microRNAs (miRNAs) are endogenous, non-coding RNA molecules that have recently been discovered as fundamental and post-transcriptional regulators of gene expression. The capacity of microRNAs to regulate the cell state and function through post-transcriptionally silencing hundreds of genes are being acknowledged as an important factor in the pathophysiology of both acute and chronic CNS injuries. In this study, we have summarized the knowledge concerning the pathophysiology of several neurological disorders, and the role of most canonical miRNAs in their development. We have focused on the miR-20, the miR-17 similar to 92 family to which miR-20 belongs, and their function in the normal development and disease of the CNS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cells

ISSN

2073-4409

e-ISSN

2073-4409

Svazek periodika

11

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

22

Strana od-do

1525

Kód UT WoS článku

000794498300001

EID výsledku v databázi Scopus

2-s2.0-85129680161