Antikoagulační léčiva zvyšují aktivitu přirozených zabíječských buněk u rakoviny plic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00027786" target="_blank" >RIV/68378050:_____/05:00027786 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/05:00000589

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Anticoagulant drugs increase natural killer cell activity in lung cancer

Popis výsledku v původním jazyce

We wanted to determine the effect of some anticoagulant drugs on the functional activity of natural killer (NK) cells. Cytotoxic activity in patients with early, operable stages of non-small-cell lung cancer was compared with healthy volunteers and studied in tumor-bearing animals. Patients were characterized by significantly lower NK cell cytotoxicity than healthy donors. NK cell activation was found in both in vitro experiments using PBMC from healthy donors and ex vivo in lung carcinoma patients after treatment with unfractionated heparin and fraxiparine. Similarly, potentiation of NK cell activity in Lewis lung carcinoma-bearing mice was found after therapy with unfractionated heparin. NK cell activation was increased by LMWHs. Other anticoagulantsaugment the effector function of NK cells in cancer patients and in an animal model of lung cancer. This is a novel effect of these compounds, which were thought previously to exert their effect only via their anticoagulant properties.

Název v anglickém jazyce

Anticoagulant drugs increase natural killer cell activity in lung cancer

Popis výsledku anglicky

We wanted to determine the effect of some anticoagulant drugs on the functional activity of natural killer (NK) cells. Cytotoxic activity in patients with early, operable stages of non-small-cell lung cancer was compared with healthy volunteers and studied in tumor-bearing animals. Patients were characterized by significantly lower NK cell cytotoxicity than healthy donors. NK cell activation was found in both in vitro experiments using PBMC from healthy donors and ex vivo in lung carcinoma patients after treatment with unfractionated heparin and fraxiparine. Similarly, potentiation of NK cell activity in Lewis lung carcinoma-bearing mice was found after therapy with unfractionated heparin. NK cell activation was increased by LMWHs. Other anticoagulantsaugment the effector function of NK cells in cancer patients and in an animal model of lung cancer. This is a novel effect of these compounds, which were thought previously to exert their effect only via their anticoagulant properties.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lung Cancer

ISSN

0169-5002

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

9

Strana od-do

215-223

Kód UT WoS článku

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EID výsledku v databázi Scopus

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