Identifikace konservovaných alternativních a antisense transcriptů Pdcd2 genu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00082617" target="_blank" >RIV/68378050:_____/07:00082617 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Conserved alternative and antisense transcripts at the programmed cell death 2 locus

Popis výsledku v původním jazyce

The Pdcd2 gene on mouse Chr 17 was evaluated as a member of a highly conserved synteny, a candidate for an imprinted locus and for the Hst1 gene. New mouse transcripts were identified at this locus as alternative transcripts of the neighboring Tbp gene located mainly in the cell nucleus: an alternative Pdcd2 mRNA skipping the last 2 coding exons and 2 classes of antisense RNAs. Analogous alternative PDCD2 forms truncating the C-terminal domain were also detected in human and chicken. This finding suggests the biological importance of such truncated protein. The identified Tbp-alternative Pdcd2-antisense transcripts may interfere with the transcription of the Pdcd2 gene, as they are transcribed at a comparable level. The conservation of the Pdcd2/Tbp sense-antisense overlap in the mouse and chicken points out its biological relevance. Some cDNAs in databases labeled as noncoding thus may be incomplete alternative cDNAs of neighboring protein-coding genes.

Název v anglickém jazyce

Conserved alternative and antisense transcripts at the programmed cell death 2 locus

Popis výsledku anglicky

The Pdcd2 gene on mouse Chr 17 was evaluated as a member of a highly conserved synteny, a candidate for an imprinted locus and for the Hst1 gene. New mouse transcripts were identified at this locus as alternative transcripts of the neighboring Tbp gene located mainly in the cell nucleus: an alternative Pdcd2 mRNA skipping the last 2 coding exons and 2 classes of antisense RNAs. Analogous alternative PDCD2 forms truncating the C-terminal domain were also detected in human and chicken. This finding suggests the biological importance of such truncated protein. The identified Tbp-alternative Pdcd2-antisense transcripts may interfere with the transcription of the Pdcd2 gene, as they are transcribed at a comparable level. The conservation of the Pdcd2/Tbp sense-antisense overlap in the mouse and chicken points out its biological relevance. Some cDNAs in databases labeled as noncoding thus may be incomplete alternative cDNAs of neighboring protein-coding genes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

B M C Genomics

ISSN

1471-2164

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

-

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

20

Kód UT WoS článku

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EID výsledku v databázi Scopus

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