Eliminace adaptorového proteinu LIME jen minimálně ovlivňuje vývoj a funkci T a B lymfocytů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00093990" target="_blank" >RIV/68378050:_____/07:00093990 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deletion of the LIME adaptor protein minimally affects T and B cell development and function

Popis výsledku v původním jazyce

LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence ofT cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors.

Název v anglickém jazyce

Deletion of the LIME adaptor protein minimally affects T and B cell development and function

Popis výsledku anglicky

LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence ofT cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/1M0506" target="_blank" >1M0506: Centrum molekulární a buněčné imunologie</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Immunology

ISSN

0014-2980

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

3259-3269

Kód UT WoS článku

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EID výsledku v databázi Scopus

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