Analogy vitaminu E a imunitní odpověď při léčení rakoviny

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00097138" target="_blank" >RIV/68378050:_____/07:00097138 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Vitamin E analogues and immune response in cancer treatment

Popis výsledku v původním jazyce

Chemotherapeutic drugs induce both proliferation arrest and apoptosis; however, some cancer cells become resistant. The suppression of the immune system by chemotherapeutic agents promotes the development and propagation of various malignancies, and maintain a cytokine milieu that favors proliferation by inhibiting apoptosis. A novel approach is based on a synergistic effect of different anticancer agents with different modes of action. Recently, a redox-silent analogue of vitamin E, ? tocopheryl succinate (? TOS), has come into focus due to its anticancer properties. It exerts pleiotropic responses in malignant cells leading to cell cycle arrest, differentiation, and apoptosis. Apart from its role in killing cancer cells, ? TOS affects expression of genes in a subapoptotic manner. Here, we review recent findings on a cooperative antitumor effect when ? TOS was combined with immunological agents. It suggests a novel strategy for cancer treatment involving enhanced immune surveillance.

Název v anglickém jazyce

Vitamin E analogues and immune response in cancer treatment

Popis výsledku anglicky

Chemotherapeutic drugs induce both proliferation arrest and apoptosis; however, some cancer cells become resistant. The suppression of the immune system by chemotherapeutic agents promotes the development and propagation of various malignancies, and maintain a cytokine milieu that favors proliferation by inhibiting apoptosis. A novel approach is based on a synergistic effect of different anticancer agents with different modes of action. Recently, a redox-silent analogue of vitamin E, ? tocopheryl succinate (? TOS), has come into focus due to its anticancer properties. It exerts pleiotropic responses in malignant cells leading to cell cycle arrest, differentiation, and apoptosis. Apart from its role in killing cancer cells, ? TOS affects expression of genes in a subapoptotic manner. Here, we review recent findings on a cooperative antitumor effect when ? TOS was combined with immunological agents. It suggests a novel strategy for cancer treatment involving enhanced immune surveillance.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vitamins and Hormones

ISSN

0083-6729

e-ISSN

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Svazek periodika

76

Číslo periodika v rámci svazku

-

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

29

Strana od-do

463-491

Kód UT WoS článku

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EID výsledku v databázi Scopus

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