Apoptóza indukovaná alfa-tokoferylsukcinátem v buňkách rakoviny žaludku je modulována proteinkinázami ERK1/2 a c-Jun bifázickým způsobem

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00097145" target="_blank" >RIV/68378050:_____/07:00097145 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

alpha-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

Popis výsledku v původním jazyce

Stomach cancer is the frequent cause of cancer-related deaths with poor prognosis. Here we studied the effect of ? tocopheryl succinate (? TOS ) on the gastric cancer cell line SGC-7901. ? TOS inhibited proliferation of the cells and induced their apoptosis in a concentration- and time-dependent manner, while ?-tocopherol showed no effect. The effect of ? TOS was modulated by components of the MAPK signaling network, including ERK1/2 and c-Jun N-terminal kinase (JNK), but not p38. Activation of ERK1/2 occurred early and increased until 12 h, coinciding with an increase in apoptosis, then it dropped abruptly, while activation of JNK rose steadily, reaching a plateau at 12 h of ? TOS treatment. The effects of ERK1/2 and JNK on the apoptosis outcome are transmitted via c-Jun, since transfection of the cells with c-Jun antisense oligodeoxynucleotide inhibited ? TOS-induced apoptosis. We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by ? TOS.

Název v anglickém jazyce

alpha-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner

Popis výsledku anglicky

Stomach cancer is the frequent cause of cancer-related deaths with poor prognosis. Here we studied the effect of ? tocopheryl succinate (? TOS ) on the gastric cancer cell line SGC-7901. ? TOS inhibited proliferation of the cells and induced their apoptosis in a concentration- and time-dependent manner, while ?-tocopherol showed no effect. The effect of ? TOS was modulated by components of the MAPK signaling network, including ERK1/2 and c-Jun N-terminal kinase (JNK), but not p38. Activation of ERK1/2 occurred early and increased until 12 h, coinciding with an increase in apoptosis, then it dropped abruptly, while activation of JNK rose steadily, reaching a plateau at 12 h of ? TOS treatment. The effects of ERK1/2 and JNK on the apoptosis outcome are transmitted via c-Jun, since transfection of the cells with c-Jun antisense oligodeoxynucleotide inhibited ? TOS-induced apoptosis. We conclude that ERK1/2 and JNK positively regulate apoptosis induced in gastric cancer cells by ? TOS.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer letters

ISSN

0304-3835

e-ISSN

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Svazek periodika

247

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

345-352

Kód UT WoS článku

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EID výsledku v databázi Scopus

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