Emerging microtubule targets in glioma therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455817" target="_blank" >RIV/68378050:_____/15:00455817 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.spen.2015.03.009" target="_blank" >http://dx.doi.org/10.1016/j.spen.2015.03.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.spen.2015.03.009" target="_blank" >10.1016/j.spen.2015.03.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Emerging microtubule targets in glioma therapy

Popis výsledku v původním jazyce

Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Current knowledge of microtubules in cancer and the development of new microtubule-based treatment strategies for high-grade gliomas are the topic in this review article. Discussed are cellular, molecular, and pharmacologic aspects of the microtubule cytoskeletonunderlying mitosis and interactions with other cellular partners involved in cell cycle progression, directional cell migration, and tumor invasion. Special focus is placed on (1) the aberrant overexpression of beta III-tubulin, a survival factor associated with hypoxic tumor microenvironment and dynamic instability of microtubules; (2) the ectopic overexpression of gamma-tubulin, which in addition to its conventional role as a microtubule-nucleating protein has recently emerged as a tra

Název v anglickém jazyce

Emerging microtubule targets in glioma therapy

Popis výsledku anglicky

Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Current knowledge of microtubules in cancer and the development of new microtubule-based treatment strategies for high-grade gliomas are the topic in this review article. Discussed are cellular, molecular, and pharmacologic aspects of the microtubule cytoskeletonunderlying mitosis and interactions with other cellular partners involved in cell cycle progression, directional cell migration, and tumor invasion. Special focus is placed on (1) the aberrant overexpression of beta III-tubulin, a survival factor associated with hypoxic tumor microenvironment and dynamic instability of microtubules; (2) the ectopic overexpression of gamma-tubulin, which in addition to its conventional role as a microtubule-nucleating protein has recently emerged as a tra

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Seminars in Pediatric Neurology

ISSN

1071-9091

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

23

Strana od-do

49-72

Kód UT WoS článku

000355021000009

EID výsledku v databázi Scopus

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