Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455879" target="_blank" >RIV/68378050:_____/15:00455879 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >http://dx.doi.org/10.1016/bs.ctdb.2015.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >10.1016/bs.ctdb.2015.06.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse

Popis výsledku v původním jazyce

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which results in loss of oocyte identity, and reprogramming of gene expression during the course of zygotic gene activation, which occurs primarily during the two-cell stage and confers blastomere totipotency. Full-grown oocytes are transcriptionally quiescent and mRNAs are remarkably stable in oocytes due to the RNA-binding protein MSY2, which stabilizes mRNAs, and low activity of the 5' and 3' RNA degradation machinery. Oocyte maturation initiates a transition from mRNA stability to instability due to phosphorylation of MSY2, which makes mRNAs more susceptible to the RNA degradation machinery, and recruitment of dormant maternal mRNAs that encode for critical components of the 5' and 3' RNA degradation machinery. Small RNAs (miRNA, siRNA, and piRNA) play little, if any, role in mRNA degradation that occurs d

Název v anglickém jazyce

Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse

Popis výsledku anglicky

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which results in loss of oocyte identity, and reprogramming of gene expression during the course of zygotic gene activation, which occurs primarily during the two-cell stage and confers blastomere totipotency. Full-grown oocytes are transcriptionally quiescent and mRNAs are remarkably stable in oocytes due to the RNA-binding protein MSY2, which stabilizes mRNAs, and low activity of the 5' and 3' RNA degradation machinery. Oocyte maturation initiates a transition from mRNA stability to instability due to phosphorylation of MSY2, which makes mRNAs more susceptible to the RNA degradation machinery, and recruitment of dormant maternal mRNAs that encode for critical components of the 5' and 3' RNA degradation machinery. Small RNAs (miRNA, siRNA, and piRNA) play little, if any, role in mRNA degradation that occurs d

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Topics in Developmental Biology

ISSN

0070-2153

e-ISSN

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Svazek periodika

113

Číslo periodika v rámci svazku

Jul 29

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

45

Strana od-do

305-349

Kód UT WoS článku

000370507900009

EID výsledku v databázi Scopus

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