Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00463316" target="_blank" >RIV/68378050:_____/16:00463316 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/16:00463316 RIV/61388963:_____/16:00471803

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.pt.2016.05.015" target="_blank" >http://dx.doi.org/10.1016/j.pt.2016.05.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pt.2016.05.015" target="_blank" >10.1016/j.pt.2016.05.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Popis výsledku v původním jazyce

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.

Název v anglickém jazyce

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

Popis výsledku anglicky

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Parasitology

ISSN

1471-4922

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

708-723

Kód UT WoS článku

000383302000008

EID výsledku v databázi Scopus

2-s2.0-84991672014