A minimum number of autoimmune T cells to induce autoimmunity?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00477930" target="_blank" >RIV/68378050:_____/17:00477930 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cellimm.2017.03.002" target="_blank" >http://dx.doi.org/10.1016/j.cellimm.2017.03.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cellimm.2017.03.002" target="_blank" >10.1016/j.cellimm.2017.03.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A minimum number of autoimmune T cells to induce autoimmunity?

Popis výsledku v původním jazyce

While autoimmune T cells are present in most individuals, only a minority of the population suffers from an autoimmune disease. To better appreciate the limits of T cell tolerance, we carried out experiments to determine how many autoimmune T cells are required to initiate an experimental autoimmune disease. Variable numbers of autoimmune OT-I T cells were transferred into RIP-OVA mice, which were injected with antigen-loaded DCs in a single footpad, this restricted T cell priming to a few OT-I T cells that are present in the draining popliteal lymph node. Using selective plane illumination microscopy (SPIM) we counted the number of OT-I T cells present in the popliteal lymph node at the time of priming. Analysis of our data suggests that a single autoimmune T cell cannot induce an experimental autoimmune disease, but a 'quorum' of 2-5 autoimmune T cells clearly has this capacity. (C) 2017 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

A minimum number of autoimmune T cells to induce autoimmunity?

Popis výsledku anglicky

While autoimmune T cells are present in most individuals, only a minority of the population suffers from an autoimmune disease. To better appreciate the limits of T cell tolerance, we carried out experiments to determine how many autoimmune T cells are required to initiate an experimental autoimmune disease. Variable numbers of autoimmune OT-I T cells were transferred into RIP-OVA mice, which were injected with antigen-loaded DCs in a single footpad, this restricted T cell priming to a few OT-I T cells that are present in the draining popliteal lymph node. Using selective plane illumination microscopy (SPIM) we counted the number of OT-I T cells present in the popliteal lymph node at the time of priming. Analysis of our data suggests that a single autoimmune T cell cannot induce an experimental autoimmune disease, but a 'quorum' of 2-5 autoimmune T cells clearly has this capacity. (C) 2017 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/GJ16-09208Y" target="_blank" >GJ16-09208Y: Vliv signalizace T-buněčného receptoru na vývoj a diferenciaci periferních T-lymfocytů v homeostázi a při zánětu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellular Immunology

ISSN

0008-8749

e-ISSN

—

Svazek periodika

316

Číslo periodika v rámci svazku

jaro

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

21-31

Kód UT WoS článku

000402949100003

EID výsledku v databázi Scopus

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