Regulation of microtubule nucleation mediated by gamma-tubulin complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00487077" target="_blank" >RIV/68378050:_____/17:00487077 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00709-016-1070-z" target="_blank" >http://dx.doi.org/10.1007/s00709-016-1070-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-016-1070-z" target="_blank" >10.1007/s00709-016-1070-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Regulation of microtubule nucleation mediated by gamma-tubulin complexes

Popis výsledku v původním jazyce

The microtubule cytoskeleton is critically important for spatio-temporal organization of eukaryotic cells. The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma-tubulin that assembles into multisubunit complexes of various sizes. gamma-Tubulin ring complexes (TuRCs) are efficient microtubule nucleators and are associated with large number of targeting, activating and modulating proteins. gamma-Tubulin-dependent nucleation of microtubules occurs both from canonical MTOCs, such as spindle pole bodies and centrosomes, and additional sites such as Golgi apparatus, nuclear envelope, plasma membrane-associated sites, chromatin and surface of pre-existing microtubules. Despite many advances in structure of gamma-tubulin complexes and characterization of gamma TuRC interacting factors, regulatory mechanisms of microtubule nucleation are not fully understood. Here, we review recent work on the factors and regulatory mechanisms that are involved in centrosomal and non-centrosomal microtubule nucleation.

Název v anglickém jazyce

Regulation of microtubule nucleation mediated by gamma-tubulin complexes

Popis výsledku anglicky

The microtubule cytoskeleton is critically important for spatio-temporal organization of eukaryotic cells. The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma-tubulin that assembles into multisubunit complexes of various sizes. gamma-Tubulin ring complexes (TuRCs) are efficient microtubule nucleators and are associated with large number of targeting, activating and modulating proteins. gamma-Tubulin-dependent nucleation of microtubules occurs both from canonical MTOCs, such as spindle pole bodies and centrosomes, and additional sites such as Golgi apparatus, nuclear envelope, plasma membrane-associated sites, chromatin and surface of pre-existing microtubules. Despite many advances in structure of gamma-tubulin complexes and characterization of gamma TuRC interacting factors, regulatory mechanisms of microtubule nucleation are not fully understood. Here, we review recent work on the factors and regulatory mechanisms that are involved in centrosomal and non-centrosomal microtubule nucleation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LD13015" target="_blank" >LD13015: Mikrotubuly v aktivovaných žírných buňkách - cíle pro inovativní terapie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Protoplasma

ISSN

0033-183X

e-ISSN

—

Svazek periodika

254

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

13

Strana od-do

1187-1199

Kód UT WoS článku

000399037400006

EID výsledku v databázi Scopus

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