LINE-1 repression in human cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00502875" target="_blank" >RIV/68378050:_____/19:00502875 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

LINE-1 repression in human cancer

Popis výsledku v původním jazyce

The LINE-1 retrotransposon comprises 17% of the human genome, although only a few intact copies currently remain “hot”, capable of retrotransposition. LINE-1 elements have long been used as a cancer biomarker and, more recently, their expression has been associated with residual cancer stem cells resistant to chemotherapy. This poses a challenge as LINE-1 derepression can result in further cancer-driving mutations, both through somatic retrotransposition or through inter-LINE-1 recombination. FAM208A and other members of the HUSH (human silencing hub) complex have recently emerged as novel restriction factors for LINE-1 transposable elements. We will discuss these findings in context with previously known functions of the HUSH complex and discuss the prospectivity of targeting this complex for cancer treatment.

Název v anglickém jazyce

LINE-1 repression in human cancer

Popis výsledku anglicky

The LINE-1 retrotransposon comprises 17% of the human genome, although only a few intact copies currently remain “hot”, capable of retrotransposition. LINE-1 elements have long been used as a cancer biomarker and, more recently, their expression has been associated with residual cancer stem cells resistant to chemotherapy. This poses a challenge as LINE-1 derepression can result in further cancer-driving mutations, both through somatic retrotransposition or through inter-LINE-1 recombination. FAM208A and other members of the HUSH (human silencing hub) complex have recently emerged as novel restriction factors for LINE-1 transposable elements. We will discuss these findings in context with previously known functions of the HUSH complex and discuss the prospectivity of targeting this complex for cancer treatment.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Chemical Biology

ISBN

978-80-88011-03-3

Počet stran výsledku

9

Strana od-do

64-75

Počet stran knihy

210

Název nakladatele

OPTIO CZ

Místo vydání

Praha

Kód UT WoS kapitoly

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