Aire-expressing ILC3-like cells in the lymph node display potent APC features

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00505103" target="_blank" >RIV/68378050:_____/19:00505103 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/19:10403708

Výsledek na webu

<a href="https://rupress.org/jem/article/216/5/1027/121004/Aireexpressing-ILC3like-cells-in-the-lymph-node" target="_blank" >https://rupress.org/jem/article/216/5/1027/121004/Aireexpressing-ILC3like-cells-in-the-lymph-node</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1084/jem.20181430" target="_blank" >10.1084/jem.20181430</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Aire-expressing ILC3-like cells in the lymph node display potent APC features

Popis výsledku v původním jazyce

The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the ´promiscuous´ expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of ´classical´ hematopoietic lineage markers, and dependence on ROR gamma t. Aire(+) cells are more frequent among lineage-negative ROR gamma t(+) cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4(+). T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.

Název v anglickém jazyce

Aire-expressing ILC3-like cells in the lymph node display potent APC features

Popis výsledku anglicky

The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the ´promiscuous´ expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of ´classical´ hematopoietic lineage markers, and dependence on ROR gamma t. Aire(+) cells are more frequent among lineage-negative ROR gamma t(+) cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory molecules, and efficiently present an endogenously expressed model antigen to CD4(+). T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Medicine

ISSN

0022-1007

e-ISSN

—

Svazek periodika

216

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

1027-1037

Kód UT WoS článku

000466981400007

EID výsledku v databázi Scopus

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