Nuclear Phosphoinositides-Versatile Regulators of Genome Functions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00521616" target="_blank" >RIV/68378050:_____/19:00521616 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2073-4409/8/7/649" target="_blank" >https://www.mdpi.com/2073-4409/8/7/649</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells8070649" target="_blank" >10.3390/cells8070649</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nuclear Phosphoinositides-Versatile Regulators of Genome Functions

Popis výsledku v původním jazyce

The many functions of phosphoinositides in cytosolic signaling were extensively studied, however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies.

Název v anglickém jazyce

Nuclear Phosphoinositides-Versatile Regulators of Genome Functions

Popis výsledku anglicky

The many functions of phosphoinositides in cytosolic signaling were extensively studied, however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cells

ISSN

2073-4409

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

—

Kód UT WoS článku

000478902000041

EID výsledku v databázi Scopus

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