RNAi and miRNA pathways in mammals II – biological roles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523486" target="_blank" >RIV/68378050:_____/19:00523486 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

RNAi and miRNA pathways in mammals II – biological roles

Popis výsledku v původním jazyce

RNA silencing denotes sequence-specific repression mediated by small RNAs. In mammals, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression. It has been implicated in many biological processes and majority of mammalian genes appear to be directly or indirectly exposed to miRNA-mediated regulations. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements, although it occasionally also acquired function in protein-coding gene regulation. The function of RNAi in mammals is still poorly understood but it is clear that proteins supporting RNAi are also involved in miRNA biogenesis and function. Because of the large volume of the existing literature, the review of mammalian miRNA and RNAi pathways was divided into two parts, where first one reviewed components of the pathways and the second one, presented here, reviews roles and significance of the pathways.

Název v anglickém jazyce

RNAi and miRNA pathways in mammals II – biological roles

Popis výsledku anglicky

RNA silencing denotes sequence-specific repression mediated by small RNAs. In mammals, there are two closely related pathways, which share several protein factors: RNA interference (RNAi) and microRNA (miRNA) pathway. The miRNA pathway serves to regulate endogenous protein-coding gene expression. It has been implicated in many biological processes and majority of mammalian genes appear to be directly or indirectly exposed to miRNA-mediated regulations. RNAi generally serves as a form of innate immunity targeting viruses and mobile elements, although it occasionally also acquired function in protein-coding gene regulation. The function of RNAi in mammals is still poorly understood but it is clear that proteins supporting RNAi are also involved in miRNA biogenesis and function. Because of the large volume of the existing literature, the review of mammalian miRNA and RNAi pathways was divided into two parts, where first one reviewed components of the pathways and the second one, presented here, reviews roles and significance of the pathways.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: Národní infrastruktura chemické biologie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Introduction to RNAi and miRNA pathways

ISBN

978-80-246-4372-4

Počet stran výsledku

40

Strana od-do

1-339

Počet stran knihy

339

Název nakladatele

Karolinum

Místo vydání

Praha

Kód UT WoS kapitoly

—