Narcissistic T cells: reactivity to self makes a difference

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00531950" target="_blank" >RIV/68378050:_____/21:00531950 - isvavai.cz</a>

Výsledek na webu

<a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15498</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/febs.15498" target="_blank" >10.1111/febs.15498</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Narcissistic T cells: reactivity to self makes a difference

Popis výsledku v původním jazyce

It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Overall, the relative difference in the self-reactivity among peripheral T cells is an important factor contributing to the diversity of T-cell responses to foreign antigens.

Název v anglickém jazyce

Narcissistic T cells: reactivity to self makes a difference

Popis výsledku anglicky

It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Overall, the relative difference in the self-reactivity among peripheral T cells is an important factor contributing to the diversity of T-cell responses to foreign antigens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naivní, paměťové a virtuální paměťové buňky v adaptivních imunitních odpovědích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FEBS Journal

ISSN

1742-464X

e-ISSN

1742-4658

Svazek periodika

288

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

1778-1788

Kód UT WoS článku

000557716300001

EID výsledku v databázi Scopus

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