Three new genes associated with longevity in the European Bison

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00560533" target="_blank" >RIV/68378050:_____/22:00560533 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2451943X22000370?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2451943X22000370?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vas.2022.100266" target="_blank" >10.1016/j.vas.2022.100266</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Three new genes associated with longevity in the European Bison

Popis výsledku v původním jazyce

Longevity-related genes have been found in humans, mice, dogs and in several other animal species. The goal of this study was to perform genetic analysis of long-lived European bisons with the aim to find genes that are associated with longevity using GWAS and further sequencing of a wider sample panel. European bison has a unique history of near extinction and the recovery of the species from just a few founder individuals. Together with the short medium lifespan, the expected genetic homogeneity makes bison a suitable model for studying longevity. Particular single nucleotide polymorphisms within three genes, BCKDHB, FER1L6 and SERPINI2, were found significantly overrepresented in long-lived European bisons. In SERPINI2, the longevity-associated single nucleotide polymorphism localizes to an exon. In the protein encoded by the SERPINI2 gene, amino acid leucine present in the reference European bisons is replaced by tryptophan in the long-lived animals. This study is the first to determine longevity-associated variants in genes in European bison. Association of the FER1L6 gene with longevity shows a possible sex dependency.

Název v anglickém jazyce

Three new genes associated with longevity in the European Bison

Popis výsledku anglicky

Longevity-related genes have been found in humans, mice, dogs and in several other animal species. The goal of this study was to perform genetic analysis of long-lived European bisons with the aim to find genes that are associated with longevity using GWAS and further sequencing of a wider sample panel. European bison has a unique history of near extinction and the recovery of the species from just a few founder individuals. Together with the short medium lifespan, the expected genetic homogeneity makes bison a suitable model for studying longevity. Particular single nucleotide polymorphisms within three genes, BCKDHB, FER1L6 and SERPINI2, were found significantly overrepresented in long-lived European bisons. In SERPINI2, the longevity-associated single nucleotide polymorphism localizes to an exon. In the protein encoded by the SERPINI2 gene, amino acid leucine present in the reference European bisons is replaced by tryptophan in the long-lived animals. This study is the first to determine longevity-associated variants in genes in European bison. Association of the FER1L6 gene with longevity shows a possible sex dependency.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10613 - Zoology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary and Animal Sciences

ISSN

2451-943X

e-ISSN

2451-943X

Svazek periodika

17

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

100266

Kód UT WoS článku

000840773200001

EID výsledku v databázi Scopus

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