Variation in mouse chemical signals is genetically controlled and environmentally modulated

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00573981" target="_blank" >RIV/68378050:_____/23:00573981 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/23:00573981 RIV/00216208:11310/23:10469145

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-023-35450-8" target="_blank" >https://www.nature.com/articles/s41598-023-35450-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-023-35450-8" target="_blank" >10.1038/s41598-023-35450-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Variation in mouse chemical signals is genetically controlled and environmentally modulated

Popis výsledku v původním jazyce

In most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of chemical signalling. We show that there is a correspondence between urinary volatiles and proteins in the representation of genetic background, sex and environment in two house mouse subspecies Mus musculus musculus and M. m. domesticus. We found that environment has a strong influence upon proteomic and metabolomic variation and that volatile mixtures better represent males while females have surprisingly more sex-biased proteins. Using machine learning and combined-omics techniques, we identified mixtures of metabolites and proteins that are associated with biological features.

Název v anglickém jazyce

Variation in mouse chemical signals is genetically controlled and environmentally modulated

Popis výsledku anglicky

In most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of chemical signalling. We show that there is a correspondence between urinary volatiles and proteins in the representation of genetic background, sex and environment in two house mouse subspecies Mus musculus musculus and M. m. domesticus. We found that environment has a strong influence upon proteomic and metabolomic variation and that volatile mixtures better represent males while females have surprisingly more sex-biased proteins. Using machine learning and combined-omics techniques, we identified mixtures of metabolites and proteins that are associated with biological features.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

8573

Kód UT WoS článku

001001070500060

EID výsledku v databázi Scopus

2-s2.0-85160268236