Deciphering the early innate immune response to bordetella pertussis infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00581908" target="_blank" >RIV/68378050:_____/23:00581908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/23:00581908

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deciphering the early innate immune response to bordetella pertussis infection

Popis výsledku v původním jazyce

Bordetella pertussis, a strictly human pathogen, elicits a highly contagious respiratory disease known as pertussis, or whooping cough. Current mouse models enabled identification of many bacterial virulence factors and development of pertussis vaccines, but mechanisms underlying the process of B. pertussis transmission during the catarrhal phase of pertussis disease remain largely unexplored due to lack of a convenient animal model. Recently, we have used immunodeficient MyD88 knock-out mice to achieve a human-like high level of nasal mucosa infection that triggers rhinitis and catarrhal shedding of bacteria from mouse nasal cavity, yielding transmission of the infection onto co-housed adult animals.

Název v anglickém jazyce

Deciphering the early innate immune response to bordetella pertussis infection

Popis výsledku anglicky

Bordetella pertussis, a strictly human pathogen, elicits a highly contagious respiratory disease known as pertussis, or whooping cough. Current mouse models enabled identification of many bacterial virulence factors and development of pertussis vaccines, but mechanisms underlying the process of B. pertussis transmission during the catarrhal phase of pertussis disease remain largely unexplored due to lack of a convenient animal model. Recently, we have used immunodeficient MyD88 knock-out mice to achieve a human-like high level of nasal mucosa infection that triggers rhinitis and catarrhal shedding of bacteria from mouse nasal cavity, yielding transmission of the infection onto co-housed adult animals.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů