PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00585208" target="_blank" >RIV/68378050:_____/24:00585208 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388980:_____/24:00585208 RIV/60461373:22330/24:43929313 RIV/60461373:22340/24:43929313

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c00084" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c00084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.4c00084" target="_blank" >10.1021/acs.inorgchem.4c00084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Popis výsledku v původním jazyce

The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O-2((1)Delta(g)), by octahedral molybdenum (Mo-6) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo-6 cluster bearing azido ligands and the homo-bifunctional linker bis-dPEG(11)-DBCO. The resulting compound formed nanoparticles, which featured production of O-2((1)Delta(g)) and efficient cellular uptake, leading to remarkable photo- and radiotoxic effects against the prostatic adenocarcinoma TRAMP-C2 cell line. Spheroids of TRAMP-C2 cells were also used for evaluation of toxicity and phototoxicity. In vivo experiments on a mouse model demonstrated that subcutaneous injection of the nanoparticles is a safe administration mode at a dose of up to 0.08 g kg(-1). The reported results confirm the relevancy of Mo-6-based radiosensitizing nanosystems for RDT.

Název v anglickém jazyce

PEGylated Molybdenum-Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma

Popis výsledku anglicky

The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O-2((1)Delta(g)), by octahedral molybdenum (Mo-6) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo-6 cluster bearing azido ligands and the homo-bifunctional linker bis-dPEG(11)-DBCO. The resulting compound formed nanoparticles, which featured production of O-2((1)Delta(g)) and efficient cellular uptake, leading to remarkable photo- and radiotoxic effects against the prostatic adenocarcinoma TRAMP-C2 cell line. Spheroids of TRAMP-C2 cells were also used for evaluation of toxicity and phototoxicity. In vivo experiments on a mouse model demonstrated that subcutaneous injection of the nanoparticles is a safe administration mode at a dose of up to 0.08 g kg(-1). The reported results confirm the relevancy of Mo-6-based radiosensitizing nanosystems for RDT.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanočástice pro cílenou fotodynamickou terapii indukovanou RTG zářením</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

1520-510X

Svazek periodika

63

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

4419-4428

Kód UT WoS článku

001166802200001

EID výsledku v databázi Scopus

2-s2.0-85186243334