Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00491206" target="_blank" >RIV/61388980:_____/18:00491206 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/18:00491206 RIV/68407700:21340/18:00328132 RIV/60461373:22330/18:43916976

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c8tb00893k" target="_blank" >http://dx.doi.org/10.1039/c8tb00893k</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c8tb00893k" target="_blank" >10.1039/c8tb00893k</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Popis výsledku v původním jazyce

The use of radiosensitizers recently emerged as a promising approach to circumvent the depth penetration limitations of photodynamic therapy of cancer and to enhance radiotherapeutical effects. A widely explored current strategy is based on complex nanoarchitectures that facilitate the transfer of energy harvested from X-ray radiation by scintillating nanoparticles to the surrounding photosensitizer molecules to generate reactive oxygen species, mostly singlet oxygen O-2((1)Delta(g)). We describe an alternative approach aiming at a considerable simplification of the architecture. The presented nanoparticles, made of the luminescent octahedral molybdenum cluster compound (n-Bu4N)(2)[Mo6I8(OCOCF3)(6)], efficiently absorb X-rays due to the high content of heavy elements, leading to the formation of the excited triplet states that interact with molecular oxygen to produce O-2((1)Delta(g)). The activity of the nanoparticles on HeLa cells was first investigated under UVA/blue-light irradiation in order to prove the biological effects of photosensitized O-2((1)Delta(g)), there is no dark toxicity at micromolar concentrations, but strong phototoxicity in the nanomolar range. The nanoparticles significantly enhance the antiproliferative effect of X-ray radiation in vitro at lower concentration than for previously reported O-2((1)Delta(g)) radiosensitizing systems and this effect is more pronounced on cancer HeLa cells than non-cancer MRC cells. The results demonstrate that the clusterbased radiosensitizers of O-2((1)Delta(g)) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.

Název v anglickém jazyce

Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy

Popis výsledku anglicky

The use of radiosensitizers recently emerged as a promising approach to circumvent the depth penetration limitations of photodynamic therapy of cancer and to enhance radiotherapeutical effects. A widely explored current strategy is based on complex nanoarchitectures that facilitate the transfer of energy harvested from X-ray radiation by scintillating nanoparticles to the surrounding photosensitizer molecules to generate reactive oxygen species, mostly singlet oxygen O-2((1)Delta(g)). We describe an alternative approach aiming at a considerable simplification of the architecture. The presented nanoparticles, made of the luminescent octahedral molybdenum cluster compound (n-Bu4N)(2)[Mo6I8(OCOCF3)(6)], efficiently absorb X-rays due to the high content of heavy elements, leading to the formation of the excited triplet states that interact with molecular oxygen to produce O-2((1)Delta(g)). The activity of the nanoparticles on HeLa cells was first investigated under UVA/blue-light irradiation in order to prove the biological effects of photosensitized O-2((1)Delta(g)), there is no dark toxicity at micromolar concentrations, but strong phototoxicity in the nanomolar range. The nanoparticles significantly enhance the antiproliferative effect of X-ray radiation in vitro at lower concentration than for previously reported O-2((1)Delta(g)) radiosensitizing systems and this effect is more pronounced on cancer HeLa cells than non-cancer MRC cells. The results demonstrate that the clusterbased radiosensitizers of O-2((1)Delta(g)) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

26

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

4301-4307

Kód UT WoS článku

000437470100003

EID výsledku v databázi Scopus

2-s2.0-85049638622