AVIAN INTERFERON REGULATORY FACTORS (ALMOST) RESOLVED
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00602175" target="_blank" >RIV/68378050:_____/24:00602175 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/48/87" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/48/87</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
AVIAN INTERFERON REGULATORY FACTORS (ALMOST) RESOLVED
Popis výsledku v původním jazyce
Interferon regulatory factors (IRFs) are transcription factors that play a key role in anti-viral immunity response of vertebrates. After viral RNA is recognized by RIG-I-like receptors (RLR), IRF3 and IRF7 activate expression of IFN-β which is together with other type I interferons responsible for forming ISGF3 complex (formed by STAT1, STAT2 and IRF9). IRF9 protein has two domains, IRF-associated domain (IAD) that binds to STAT2 and DNA binding domain (DBD) that binds in the nucleus with interferon-stimulated response element (ISRE) in promotor of interferon-stimulated genes (ISGs) and activates their expression1,2. These pathways are well described in mammals and some other vertebrates but there is limited information available in birds. Moreover, IRF9 and IRF3 are thought to be missing in birds3even though both of the pathways are functional.
Název v anglickém jazyce
AVIAN INTERFERON REGULATORY FACTORS (ALMOST) RESOLVED
Popis výsledku anglicky
Interferon regulatory factors (IRFs) are transcription factors that play a key role in anti-viral immunity response of vertebrates. After viral RNA is recognized by RIG-I-like receptors (RLR), IRF3 and IRF7 activate expression of IFN-β which is together with other type I interferons responsible for forming ISGF3 complex (formed by STAT1, STAT2 and IRF9). IRF9 protein has two domains, IRF-associated domain (IAD) that binds to STAT2 and DNA binding domain (DBD) that binds in the nucleus with interferon-stimulated response element (ISRE) in promotor of interferon-stimulated genes (ISGs) and activates their expression1,2. These pathways are well described in mammals and some other vertebrates but there is limited information available in birds. Moreover, IRF9 and IRF3 are thought to be missing in birds3even though both of the pathways are functional.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10607 - Virology
Návaznosti výsledku
Projekt
<a href="/cs/project/LX22NPO5103" target="_blank" >LX22NPO5103: Národní institut virologie a bakteriologie</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů