Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00617708" target="_blank" >RIV/68378050:_____/25:00617708 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.vas.2024.100420" target="_blank" >https://doi.org/10.1016/j.vas.2024.100420</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vas.2024.100420" target="_blank" >10.1016/j.vas.2024.100420</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel

Popis výsledku v původním jazyce

In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: B3GALNT1, NLRP1 like, PARP14, IQCJSCHIP1, COL9A1, COL19A1, SDHAF4, B3GAT2, and DIRC2 that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan.

Název v anglickém jazyce

Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel

Popis výsledku anglicky

In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: B3GALNT1, NLRP1 like, PARP14, IQCJSCHIP1, COL9A1, COL19A1, SDHAF4, B3GAT2, and DIRC2 that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary and Animal Sciences

ISSN

2451-943X

e-ISSN

2451-943X

Svazek periodika

27

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

100420

Kód UT WoS článku

001392101100001

EID výsledku v databázi Scopus

2-s2.0-85212431339