Cell membrane pore formation and change in ion channel activity in high-gradient magnetic fields

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00493921" target="_blank" >RIV/68378271:_____/17:00493921 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1109/LMAG.2017.2732361" target="_blank" >http://dx.doi.org/10.1109/LMAG.2017.2732361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/LMAG.2017.2732361" target="_blank" >10.1109/LMAG.2017.2732361</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cell membrane pore formation and change in ion channel activity in high-gradient magnetic fields

Popis výsledku v původním jazyce

We examine membrane pores and the channel stability of cells exposed to high-gradient magnetic fields (HGMFs). As an HGMF generates stress and deformation in the cell membrane through magnetic gradient forces, stretchactivated and voltage-gated ion channels are gated by both the effective membrane tension (σ) and the membrane potential (U). By calculating a (σ, U)-phase diagram, we find an unexpected region of stability for the pores in a cell membrane subjected to an HGMF. Within this region, the cell membrane does not lose its integrity and is stable against pore creation by electric and magnetic fields. Our theoretical arguments lead to predictions for changes in membrane ion channel selectivity in cells treated with magnetic fields. Overall, the results demonstrate that HGMFs can be used as a tool to create a specific stress field in a cell to drive its machinery.

Název v anglickém jazyce

Cell membrane pore formation and change in ion channel activity in high-gradient magnetic fields

Popis výsledku anglicky

We examine membrane pores and the channel stability of cells exposed to high-gradient magnetic fields (HGMFs). As an HGMF generates stress and deformation in the cell membrane through magnetic gradient forces, stretchactivated and voltage-gated ion channels are gated by both the effective membrane tension (σ) and the membrane potential (U). By calculating a (σ, U)-phase diagram, we find an unexpected region of stability for the pores in a cell membrane subjected to an HGMF. Within this region, the cell membrane does not lose its integrity and is stable against pore creation by electric and magnetic fields. Our theoretical arguments lead to predictions for changes in membrane ion channel selectivity in cells treated with magnetic fields. Overall, the results demonstrate that HGMFs can be used as a tool to create a specific stress field in a cell to drive its machinery.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IEEE Magnetics Letters

ISSN

1949-307X

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

Jul

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000408352700001

EID výsledku v databázi Scopus

2-s2.0-85029165054