Microscopic study of zinc oxide molecular biointerface

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00537913" target="_blank" >RIV/68378271:_____/20:00537913 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Microscopic study of zinc oxide molecular biointerface

Popis výsledku v původním jazyce

We focus on the actual interface between ZnO and biological environment. At first, by using atomic force microscopy (AFM) we have studied adsorption of fetal bovine serum and bovine serum albumin on ZnO plates. Droplets of biomolecular solution were deposited on clean ZnO substrates for 10 minutes, rindsed with demi water, dried with nitrogen. We employed CF4 treated AFM tips to minimize tip contamination by biomolecules during morphology analysis. Compared to our reference, oxidized diamond surfaces, the morphology of molecular layer is similar, however, the binding forces are much stronger on ZnO. We performed atomic scale computing of the ZnO bionterface by force field method to support understanding the above effects and differences. We discuss implications for protein corona on ZnO nanostructures.

Název v anglickém jazyce

Microscopic study of zinc oxide molecular biointerface

Popis výsledku anglicky

We focus on the actual interface between ZnO and biological environment. At first, by using atomic force microscopy (AFM) we have studied adsorption of fetal bovine serum and bovine serum albumin on ZnO plates. Droplets of biomolecular solution were deposited on clean ZnO substrates for 10 minutes, rindsed with demi water, dried with nitrogen. We employed CF4 treated AFM tips to minimize tip contamination by biomolecules during morphology analysis. Compared to our reference, oxidized diamond surfaces, the morphology of molecular layer is similar, however, the binding forces are much stronger on ZnO. We performed atomic scale computing of the ZnO bionterface by force field method to support understanding the above effects and differences. We discuss implications for protein corona on ZnO nanostructures.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/GC19-02858J" target="_blank" >GC19-02858J: Přenos náboje a mikrobiologické interakce hybridních nanostruktur oxidů kovů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů