Functionalizable antifouling coatings as tunable platforms for the stress-driven manipulation of living cell machinery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00538757" target="_blank" >RIV/68378271:_____/20:00538757 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/20:00116149

Výsledek na webu

<a href="http://hdl.handle.net/11104/0316495" target="_blank" >http://hdl.handle.net/11104/0316495</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biom10081146" target="_blank" >10.3390/biom10081146</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Functionalizable antifouling coatings as tunable platforms for the stress-driven manipulation of living cell machinery

Popis výsledku v původním jazyce

Cells are continuously sensing their microenvironment and subsequently respond to di erent physicochemical cues by the activation or inhibition of di erent signaling pathways. To study a very complex cellular response, it is necessary to diminish background environmental influences and highlight the particular event. However, surface-driven nonspecific interactions of the abundant biomolecules from the environment influence the targeted cell response significantly. Yes-associated protein (YAP) translocation may serve as a marker of human hepatocellular carcinoma (Huh7) cell responses to the extracellular matrix and surface-mediated stresses. Here, we propose a platform of tunable functionable antifouling poly(carboxybetain) (pCB)-based brushes to achieve a molecularly clean background for studying arginine, glycine, and aspartic acid (RGD)-induced YAP-connected mechanotransduction.n

Název v anglickém jazyce

Functionalizable antifouling coatings as tunable platforms for the stress-driven manipulation of living cell machinery

Popis výsledku anglicky

Cells are continuously sensing their microenvironment and subsequently respond to di erent physicochemical cues by the activation or inhibition of di erent signaling pathways. To study a very complex cellular response, it is necessary to diminish background environmental influences and highlight the particular event. However, surface-driven nonspecific interactions of the abundant biomolecules from the environment influence the targeted cell response significantly. Yes-associated protein (YAP) translocation may serve as a marker of human hepatocellular carcinoma (Huh7) cell responses to the extracellular matrix and surface-mediated stresses. Here, we propose a platform of tunable functionable antifouling poly(carboxybetain) (pCB)-based brushes to achieve a molecularly clean background for studying arginine, glycine, and aspartic acid (RGD)-induced YAP-connected mechanotransduction.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Fyzika pevných látek pro 21. století</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomolecules

ISSN

2218-273X

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

000577776900001

EID výsledku v databázi Scopus

2-s2.0-85089300955