Fast UHPLC enantioseparation of liquid crystalline materials with chiral center based on octanol in reversed-phase and polar organic mode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F20%3A00560618" target="_blank" >RIV/68378271:_____/20:00560618 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/20:10413777

Výsledek na webu

<a href="https://doi.org/10.1007/s00706-020-02622-5" target="_blank" >https://doi.org/10.1007/s00706-020-02622-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-020-02622-5" target="_blank" >10.1007/s00706-020-02622-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fast UHPLC enantioseparation of liquid crystalline materials with chiral center based on octanol in reversed-phase and polar organic mode

Popis výsledku v původním jazyce

Fast baseline enantioseparation of twenty racemic liquid crystalline compounds was carried out via ultra-performance liquid chromatography through direct enantioseparation in polar organic and reversed-phase modes. Tris(3-chloro-5-methylphenylcarbamate) derivative of amylose was used as chiral stationary phase, the chiral selector was covalently mmobilized on sub-2 μm silica particles. Experiments were done using either pure acetonitrile as mobile phase or simple binary mobile phases consisting of acetonitrile/water mixtures. Studied materials are a set of structurally similar compounds comprising two different structures of chiral center, various length of alkoxy spacer and four patterns of lateral substitution of aromatic core by fluorine. The compounds do not contain any ionizable group. The effect of the enantiomer structure on the retention and enantioseparation was evaluated. Flow rate and column temperature were optimized as part of method development.

Název v anglickém jazyce

Fast UHPLC enantioseparation of liquid crystalline materials with chiral center based on octanol in reversed-phase and polar organic mode

Popis výsledku anglicky

Fast baseline enantioseparation of twenty racemic liquid crystalline compounds was carried out via ultra-performance liquid chromatography through direct enantioseparation in polar organic and reversed-phase modes. Tris(3-chloro-5-methylphenylcarbamate) derivative of amylose was used as chiral stationary phase, the chiral selector was covalently mmobilized on sub-2 μm silica particles. Experiments were done using either pure acetonitrile as mobile phase or simple binary mobile phases consisting of acetonitrile/water mixtures. Studied materials are a set of structurally similar compounds comprising two different structures of chiral center, various length of alkoxy spacer and four patterns of lateral substitution of aromatic core by fluorine. The compounds do not contain any ionizable group. The effect of the enantiomer structure on the retention and enantioseparation was evaluated. Flow rate and column temperature were optimized as part of method development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Fyzika pevných látek pro 21. století</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

151

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

6

Strana od-do

1235-1240

Kód UT WoS článku

000555979300008

EID výsledku v databázi Scopus

2-s2.0-85085570057