Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00546336" target="_blank" >RIV/68378271:_____/21:00546336 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/21:43922708 RIV/00216208:11110/21:10435128 RIV/00064165:_____/21:10435128

Výsledek na webu

<a href="http://hdl.handle.net/11104/0322890" target="_blank" >http://hdl.handle.net/11104/0322890</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ma14123271" target="_blank" >10.3390/ma14123271</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

Popis výsledku v původním jazyce

In this study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The alloy was safe, biocompatible, and well-tolerated.

Název v anglickém jazyce

Zn–0.8Mg–0.2Sr (wt.%) absorbable screws—an in-vivo biocompatibility and degradation pilot study on a rabbit model

Popis výsledku anglicky

In this study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The alloy was safe, biocompatible, and well-tolerated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials

ISSN

1996-1944

e-ISSN

1996-1944

Svazek periodika

14

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

21

Strana od-do

3271

Kód UT WoS článku

000666146700001

EID výsledku v databázi Scopus

2-s2.0-85108584632