A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00549687" target="_blank" >RIV/68378271:_____/21:00549687 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22310/21:43922747 RIV/00216208:11110/21:10436178 RIV/00064165:_____/21:10436178
Výsledek na webu
<a href="http://hdl.handle.net/11104/0325631" target="_blank" >http://hdl.handle.net/11104/0325631</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms222413444" target="_blank" >10.3390/ijms222413444</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days
Popis výsledku v původním jazyce
In this study, we analyzed an extruded Zn-0.8Mg-0.2Sr (wt.%) absorbable/biodegradable alloy on a rabbit model. Screws made of this alloy were implanted into the rabbit tibia. After 120, 240, and 360 days, we tested the toxicity at the site of implantation and also within the vital organs. The results were compared with a control group, implanted with a Ti-based screw and sacrificed after 360 days. The samples were analyzed using X-ray, micro-CT, and a scanning electron microscope. Chemical analysis revealed only small concentrations of zinc, strontium, and magnesium in the liver, kidneys, and brain. Histologically, the alloy was verified to possess very good biocompatibility after 360 days. We did not observe raised levels of Sr, Zn, or Mg in any of the vital organs when compared with the Ti group at 360 days. The material was found to slowly degrade in vivo, forming solid corrosion products on its surface.
Název v anglickém jazyce
A complex evaluation of the in-vivo biocompatibility and degradation of an extruded ZnMgSr absorbable alloy implanted into rabbit bones for 360 days
Popis výsledku anglicky
In this study, we analyzed an extruded Zn-0.8Mg-0.2Sr (wt.%) absorbable/biodegradable alloy on a rabbit model. Screws made of this alloy were implanted into the rabbit tibia. After 120, 240, and 360 days, we tested the toxicity at the site of implantation and also within the vital organs. The results were compared with a control group, implanted with a Ti-based screw and sacrificed after 360 days. The samples were analyzed using X-ray, micro-CT, and a scanning electron microscope. Chemical analysis revealed only small concentrations of zinc, strontium, and magnesium in the liver, kidneys, and brain. Histologically, the alloy was verified to possess very good biocompatibility after 360 days. We did not observe raised levels of Sr, Zn, or Mg in any of the vital organs when compared with the Ti group at 360 days. The material was found to slowly degrade in vivo, forming solid corrosion products on its surface.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
20501 - Materials engineering
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Svazek periodika
22
Číslo periodika v rámci svazku
Dec
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
24
Strana od-do
13444
Kód UT WoS článku
000737886300001
EID výsledku v databázi Scopus
2-s2.0-85121043397