Biological impact of target fragments on proton treatment plans: an analysis based on the current cross-section data and a full mixed field approach
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00563526" target="_blank" >RIV/68378271:_____/21:00563526 - isvavai.cz</a>
Výsledek na webu
<a href="https://hdl.handle.net/11104/0335476" target="_blank" >https://hdl.handle.net/11104/0335476</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers13194768" target="_blank" >10.3390/cancers13194768</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biological impact of target fragments on proton treatment plans: an analysis based on the current cross-section data and a full mixed field approach
Popis výsledku v původním jazyce
Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. This is partially due to the difficult characterization of the irradiation field. The detection of low energetic fragments, secondary protons and fragments, is in fact challenging due to their very short range. However, considering their low residual energy and therefore high LET, the possible contribution of such heavy particles to the overall biological effect could be not negligible. In this context, we performed a systematic analysis aimed at an explicit assessment of the RBE (relative biological effectiveness, i.e., the ratio of photon to proton physical dose needed to achieve the same biological effect) contribution of target fragments in the biological dose calculations of proton fields.
Název v anglickém jazyce
Biological impact of target fragments on proton treatment plans: an analysis based on the current cross-section data and a full mixed field approach
Popis výsledku anglicky
Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. This is partially due to the difficult characterization of the irradiation field. The detection of low energetic fragments, secondary protons and fragments, is in fact challenging due to their very short range. However, considering their low residual energy and therefore high LET, the possible contribution of such heavy particles to the overall biological effect could be not negligible. In this context, we performed a systematic analysis aimed at an explicit assessment of the RBE (relative biological effectiveness, i.e., the ratio of photon to proton physical dose needed to achieve the same biological effect) contribution of target fragments in the biological dose calculations of proton fields.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10305 - Fluids and plasma physics (including surface physics)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Cancers (Basel)
ISSN
2072-6694
e-ISSN
2072-6694
Svazek periodika
13
Číslo periodika v rámci svazku
19
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
23
Strana od-do
4768
Kód UT WoS článku
000708183900001
EID výsledku v databázi Scopus
2-s2.0-85115651436