Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00563784" target="_blank" >RIV/68378271:_____/22:00563784 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/22:10442306 RIV/60461373:22340/22:43923148 RIV/00216275:25310/22:39918981 RIV/00216208:11110/22:10442306 RIV/00216208:11320/22:10442306

Výsledek na webu

<a href="https://hdl.handle.net/11104/0335589" target="_blank" >https://hdl.handle.net/11104/0335589</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano12030428" target="_blank" >10.3390/nano12030428</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores

Popis výsledku v původním jazyce

Gold nanoshells with magnetic cores and complex organic functionalization may offer an efficient multimodal platform for MRI, photoacoustic imaging (PAI), and fluorescence techniques combined with pH sensing by SERS. In the present study, the synthesis of gold nanoshells with Mn-Zn ferrite cores is described, and their properties are analyzed by XRD, XRF, TEM, magnetic measurements, and UV-Vis spectroscopy. The gold surface is functionalized with four different model molecules to analyze the effect of varying charge and surface chemistry on cells in vitro. Finally, the nanoshells are functionalized with a combination of 4-mercaptobenzoic acid and 7-mercapto-4-methylcoumarin, which introduces a SERS active pH sensor and a covalently attached fluorescent tag. NMR relaxometry, fluorescence spectroscopy, and PAI demonstrate the multimodal potential of the suggested probe, including extraordinarily high transverse relaxivity, while the SERS study evidences a pH-dependent spectral response.n

Název v anglickém jazyce

Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores

Popis výsledku anglicky

Gold nanoshells with magnetic cores and complex organic functionalization may offer an efficient multimodal platform for MRI, photoacoustic imaging (PAI), and fluorescence techniques combined with pH sensing by SERS. In the present study, the synthesis of gold nanoshells with Mn-Zn ferrite cores is described, and their properties are analyzed by XRD, XRF, TEM, magnetic measurements, and UV-Vis spectroscopy. The gold surface is functionalized with four different model molecules to analyze the effect of varying charge and surface chemistry on cells in vitro. Finally, the nanoshells are functionalized with a combination of 4-mercaptobenzoic acid and 7-mercapto-4-methylcoumarin, which introduces a SERS active pH sensor and a covalently attached fluorescent tag. NMR relaxometry, fluorescence spectroscopy, and PAI demonstrate the multimodal potential of the suggested probe, including extraordinarily high transverse relaxivity, while the SERS study evidences a pH-dependent spectral response.n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nanomaterials

ISSN

2079-4991

e-ISSN

2079-4991

Svazek periodika

12

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

428

Kód UT WoS článku

000755646400001

EID výsledku v databázi Scopus

2-s2.0-85123434057