Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00587163" target="_blank" >RIV/68378271:_____/24:00587163 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/24:00084740

Výsledek na webu

<a href="https://hdl.handle.net/11104/0354436" target="_blank" >https://hdl.handle.net/11104/0354436</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbiosy.2024.100093" target="_blank" >10.1016/j.bbiosy.2024.100093</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Popis výsledku v původním jazyce

Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Mitochondria are well-known as bioenergetic, biosynthetic, and signaling organelles crucial for sensing stress and facilitating cellular adaptation to the environment and physical stimuli. Consequently, it is logical to hypothesize that mitochondria dynamics subjected to physical cues may play a pivotal role in mediating tumorigenesis. However, how cancer cell mechanics and mitochondria functions are connected, still remain poorly understood. Here, we discuss recent studies that link mechanical stimuli exerted by the tumor cell environment and mitochondria dynamics and functions. This interplay between mechanics and mitochondria functions may shed light on how mitochondria regulate tumorigenesis.

Název v anglickém jazyce

Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Popis výsledku anglicky

Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Mitochondria are well-known as bioenergetic, biosynthetic, and signaling organelles crucial for sensing stress and facilitating cellular adaptation to the environment and physical stimuli. Consequently, it is logical to hypothesize that mitochondria dynamics subjected to physical cues may play a pivotal role in mediating tumorigenesis. However, how cancer cell mechanics and mitochondria functions are connected, still remain poorly understood. Here, we discuss recent studies that link mechanical stimuli exerted by the tumor cell environment and mitochondria dynamics and functions. This interplay between mechanics and mitochondria functions may shed light on how mitochondria regulate tumorigenesis.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA22-18634S" target="_blank" >GA22-18634S: Mechanická regulace funkce mitochondrií a glykolýza v buňkách rakoviny jater</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomaterials and Biosystems

ISSN

2666-5344

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

100093

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85188991930