Development of the crystallization process for rivaroxaban−oxalic acid cocrystal preparation using a combination of phase diagrams and in situ measurements

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00618927" target="_blank" >RIV/68378271:_____/25:00618927 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22340/25:43933251

Výsledek na webu

<a href="https://hdl.handle.net/11104/0365723" target="_blank" >https://hdl.handle.net/11104/0365723</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.oprd.4c00509" target="_blank" >10.1021/acs.oprd.4c00509</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Development of the crystallization process for rivaroxaban−oxalic acid cocrystal preparation using a combination of phase diagrams and in situ measurements

Popis výsledku v původním jazyce

This study presents the development of the crystallization process for the rivaroxaban−oxalic acid cocrystal. The solvent screening was conducted by means of the crystallization of the cocrystal from a saturated solution of acetone, ethanol, isopropanol, acetonitrile, ethyl acetate, and ethyl formate. Two selected solvents, namely, ethyl formate and acetone, were subjected to ternary phase diagram construction in order to ascertain the system equilibrium and identify the boundaries for pure cocrystal crystallization. The crystallization process was subsequently examined through the utilization of an in situ Raman spectroscopy probe. It was observed that the rate of transformation decreased at higher temperatures, which is most probably due to lower saturation in terms of the cocrystal.

Název v anglickém jazyce

Development of the crystallization process for rivaroxaban−oxalic acid cocrystal preparation using a combination of phase diagrams and in situ measurements

Popis výsledku anglicky

This study presents the development of the crystallization process for the rivaroxaban−oxalic acid cocrystal. The solvent screening was conducted by means of the crystallization of the cocrystal from a saturated solution of acetone, ethanol, isopropanol, acetonitrile, ethyl acetate, and ethyl formate. Two selected solvents, namely, ethyl formate and acetone, were subjected to ternary phase diagram construction in order to ascertain the system equilibrium and identify the boundaries for pure cocrystal crystallization. The crystallization process was subsequently examined through the utilization of an in situ Raman spectroscopy probe. It was observed that the rate of transformation decreased at higher temperatures, which is most probably due to lower saturation in terms of the cocrystal.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Organic Process Research & Development

ISSN

1083-6160

e-ISSN

1520-586X

Svazek periodika

29

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

565-573

Kód UT WoS článku

001399112700001

EID výsledku v databázi Scopus

2-s2.0-85218410870