Biodegradable Zn-0.8Mg-0.2Sr alloy as an internal fixation material exhibits controlled degradation with enhanced osteogenesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00638536" target="_blank" >RIV/68378271:_____/25:00638536 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/25:43933113

Výsledek na webu

<a href="https://hdl.handle.net/11104/0369914" target="_blank" >https://hdl.handle.net/11104/0369914</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d5ra02009c" target="_blank" >10.1039/d5ra02009c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biodegradable Zn-0.8Mg-0.2Sr alloy as an internal fixation material exhibits controlled degradation with enhanced osteogenesis

Popis výsledku v původním jazyce

Zinc (Zn) and its alloys are promising candidates for biodegradable metals in medical applications. However, their clinical use in internal fixation is hindered by low mechanical strength, uncontrolled corrosion, and insufficient bioactivity. To address these issues, we developed an extruded Zn-0.8Mg-0.2Sr ternary alloy and systematically evaluated its biological performance. In vitro corrosion tests indicated that Zn-0.8Mg-0.2Sr exhibited superior corrosion resistance, attributed to a dense passivation layer that provided effective protection, controlled degradation kinetics, and milder Zn2+ release. The cytotoxicity of Zn-0.8Mg-0.2Sr toward pre-osteoblasts was concentration-dependent. Within the non-cytotoxic concentration range (Zn2+ ≤8.98 μg mL−1), Zn-0.8Mg-0.2Sr promoted osteogenic differentiation more effectively than pure Zn. Further in vivo studies confirmed favorable biocompatibility and more uniform degradation of Zn-0.8Mg-0.2Sr, with reduced pitting corrosion and structural collapse. Notably, Zn-0.8Mg-0.2Sr exhibited superior performance in promoting bone regeneration and anti-inflammatory immunomodulation compared to pure Zn. These findings highlight Zn-0.8Mg-0.2Sr as a promising alternative to conventional internal fixation materials, offering favorable biocompatibility, controlled biodegradability, and enhanced osteogenesis.

Název v anglickém jazyce

Biodegradable Zn-0.8Mg-0.2Sr alloy as an internal fixation material exhibits controlled degradation with enhanced osteogenesis

Popis výsledku anglicky

Zinc (Zn) and its alloys are promising candidates for biodegradable metals in medical applications. However, their clinical use in internal fixation is hindered by low mechanical strength, uncontrolled corrosion, and insufficient bioactivity. To address these issues, we developed an extruded Zn-0.8Mg-0.2Sr ternary alloy and systematically evaluated its biological performance. In vitro corrosion tests indicated that Zn-0.8Mg-0.2Sr exhibited superior corrosion resistance, attributed to a dense passivation layer that provided effective protection, controlled degradation kinetics, and milder Zn2+ release. The cytotoxicity of Zn-0.8Mg-0.2Sr toward pre-osteoblasts was concentration-dependent. Within the non-cytotoxic concentration range (Zn2+ ≤8.98 μg mL−1), Zn-0.8Mg-0.2Sr promoted osteogenic differentiation more effectively than pure Zn. Further in vivo studies confirmed favorable biocompatibility and more uniform degradation of Zn-0.8Mg-0.2Sr, with reduced pitting corrosion and structural collapse. Notably, Zn-0.8Mg-0.2Sr exhibited superior performance in promoting bone regeneration and anti-inflammatory immunomodulation compared to pure Zn. These findings highlight Zn-0.8Mg-0.2Sr as a promising alternative to conventional internal fixation materials, offering favorable biocompatibility, controlled biodegradability, and enhanced osteogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

<a href="/cs/project/GA23-05592S" target="_blank" >GA23-05592S: Vliv povrchových modifikací na funkční vlastnosti biodegradabilních materiálů na bázi zinku pro aplikace v oblasti kostních rekonstrukcí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

2046-2069

Svazek periodika

15

Číslo periodika v rámci svazku

37

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

30071-30088

Kód UT WoS článku

001554775300001

EID výsledku v databázi Scopus

2-s2.0-105013781736