Deformation analysis of gellan-gum based bone scaffold using on-the-fly tomography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378297%3A_____%2F17%3A00478736" target="_blank" >RIV/68378297:_____/17:00478736 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S026412751730789X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S026412751730789X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matdes.2017.08.036" target="_blank" >10.1016/j.matdes.2017.08.036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deformation analysis of gellan-gum based bone scaffold using on-the-fly tomography

Popis výsledku v původním jazyce

Porous hydrogel-based structures reinforced by bioactive nano-particles allows one to design scaffolds with controlled stiffness, strength, and permeability for bone-tissue engineering applications. To be able to reliably assess the mechanical properties, it is necessary to study the material’s deformation response on a volumetric basis and in high detail. In this paper, we present an investigation on the compressive characteristics of highly-relaxing gellan-gum bioactive-glass scaffold subjected to continuous uniaxial quasi-static compression. The sample was compressed with a loading rate of 0.4 µm·s-1 and simultaneously irradiated by X-rays during several micro-tomographical scans to obtain data for the evaluation of the deformation and strain fields using digital volume correlation (DVC). Such DVC evaluated on-the-fly micro-tomography was very challenging due to the low thickness of cell-walls and the material’s intrinsic low attenuation of X-rays. Thus, we employed loading and tomographical devices equipped with a single-photon counting detector coupled with a DVC procedure, all developed in-house. From the acquired 34 tomographical scans, high-resolution voxel models with a resolution of 29.77 lm were developed and subjected to DVC to obtain detailed deformation and strain fields of the material. It is shown that the presented method is suitable for the precise determination of the deformation response of the predominantly organic material developed as a biocompatible, bioresorbable bone scaffold.

Název v anglickém jazyce

Deformation analysis of gellan-gum based bone scaffold using on-the-fly tomography

Popis výsledku anglicky

Porous hydrogel-based structures reinforced by bioactive nano-particles allows one to design scaffolds with controlled stiffness, strength, and permeability for bone-tissue engineering applications. To be able to reliably assess the mechanical properties, it is necessary to study the material’s deformation response on a volumetric basis and in high detail. In this paper, we present an investigation on the compressive characteristics of highly-relaxing gellan-gum bioactive-glass scaffold subjected to continuous uniaxial quasi-static compression. The sample was compressed with a loading rate of 0.4 µm·s-1 and simultaneously irradiated by X-rays during several micro-tomographical scans to obtain data for the evaluation of the deformation and strain fields using digital volume correlation (DVC). Such DVC evaluated on-the-fly micro-tomography was very challenging due to the low thickness of cell-walls and the material’s intrinsic low attenuation of X-rays. Thus, we employed loading and tomographical devices equipped with a single-photon counting detector coupled with a DVC procedure, all developed in-house. From the acquired 34 tomographical scans, high-resolution voxel models with a resolution of 29.77 lm were developed and subjected to DVC to obtain detailed deformation and strain fields of the material. It is shown that the presented method is suitable for the precise determination of the deformation response of the predominantly organic material developed as a biocompatible, bioresorbable bone scaffold.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials and Design

ISSN

0264-1275

e-ISSN

—

Svazek periodika

134

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

400-417

Kód UT WoS článku

000411896200041

EID výsledku v databázi Scopus

2-s2.0-85029166619