Cartilage Boundary lubrication ? Theory of self-assembling nanolayers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F13%3A00216682" target="_blank" >RIV/68407700:21220/13:00216682 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cartilage Boundary lubrication ? Theory of self-assembling nanolayers

Popis výsledku v původním jazyce

Articular cartilage has a frictional properties that remains unmatched by industrial joints. The mechanisms by which the synovial joint achieves these properties involve combination of biomechanical and biomolecular factors. Synovial fluid plays multipleroles in joint lubrication by providing a high viscosity "squeeze film" layer that delays cartilage to cartilage contact under compression but also serves as a source of boundary lubricant molecules within the joint. The principles of cartilage lubrication has been studied for many decades, but the exact lubrication mechanism remains unclear. In the last decades, it has been proposed that surface-active phospholipids (SAPL) serve as the major boundary lubricant. Lamellar structures of phospholipids reduce the coeffcient of friction thus lessening wear of the articular surfaces, even under high loads. The aim of this contribution is to propose mechanisms of cartilage lubrication mediated by self-assembling phospholipid layers.

Název v anglickém jazyce

Cartilage Boundary lubrication ? Theory of self-assembling nanolayers

Popis výsledku anglicky

Articular cartilage has a frictional properties that remains unmatched by industrial joints. The mechanisms by which the synovial joint achieves these properties involve combination of biomechanical and biomolecular factors. Synovial fluid plays multipleroles in joint lubrication by providing a high viscosity "squeeze film" layer that delays cartilage to cartilage contact under compression but also serves as a source of boundary lubricant molecules within the joint. The principles of cartilage lubrication has been studied for many decades, but the exact lubrication mechanism remains unclear. In the last decades, it has been proposed that surface-active phospholipids (SAPL) serve as the major boundary lubricant. Lamellar structures of phospholipids reduce the coeffcient of friction thus lessening wear of the articular surfaces, even under high loads. The aim of this contribution is to propose mechanisms of cartilage lubrication mediated by self-assembling phospholipid layers.

Druh

O - Ostatní výsledky

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

<a href="/cs/project/TA01010185" target="_blank" >TA01010185: Nové materiály a povrchové vrstvy pro bionický návrh kloubních náhrad</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů