Stability of Phospholipid Vesicles in Joint - Mathematical Model
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F15%3A00241367" target="_blank" >RIV/68407700:21220/15:00241367 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Stability of Phospholipid Vesicles in Joint - Mathematical Model
Popis výsledku v původním jazyce
Articular cartilage has a frictional properties that remains unmatched by industrial joints. The mechanisms by which the synovial joint achieves these properties involve combination of biomechanical and biomolecular factors. The principles of cartilage lubrication has been studied for many decades, but the exact lubrication mechanism remains unclear. In the last decades, it has been proposed that surface-active phospholipids (SAPL) serve as the boundary lubricant. Lamellar structures of phospholipids reduce the coefficient of friction thus lessening wear of the articular surfaces, even under high loads. The aim of this study is to test the hypothesis whether or not phospholipid vesicles in synovial fluid may contribute to creation of lamellar layer at cartilage under physiological load.
Název v anglickém jazyce
Stability of Phospholipid Vesicles in Joint - Mathematical Model
Popis výsledku anglicky
Articular cartilage has a frictional properties that remains unmatched by industrial joints. The mechanisms by which the synovial joint achieves these properties involve combination of biomechanical and biomolecular factors. The principles of cartilage lubrication has been studied for many decades, but the exact lubrication mechanism remains unclear. In the last decades, it has been proposed that surface-active phospholipids (SAPL) serve as the boundary lubricant. Lamellar structures of phospholipids reduce the coefficient of friction thus lessening wear of the articular surfaces, even under high loads. The aim of this study is to test the hypothesis whether or not phospholipid vesicles in synovial fluid may contribute to creation of lamellar layer at cartilage under physiological load.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
BO - Biofyzika
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů