Microwave Applicator for Hyperthermia Treatment on in Vivo Melanoma Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F10%3A00161903" target="_blank" >RIV/68407700:21230/10:00161903 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/10:00350314

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Microwave Applicator for Hyperthermia Treatment on in Vivo Melanoma Model

Popis výsledku v původním jazyce

This work evaluates a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in the tumor-bearing animals. The study was firstly performed by simulations of SAR distribution inside a homogeneous phantom, considering an integrated water bolus. Further tests were performed on homogeneous agar phantomto simulate the temperature distribution in the biological tissue and to assess the possible modality and schedule of hyperthermia delivery. The in vivo experiments showed the evidence of microwave-induced heating and damage of the melanoma tissue in arange of penetration coherent both with simulations and phantom studies. This approach appears perspective for designing limited microwave-delivery applicators for treatments of human superficial tumors and pre-tumoral les

Název v anglickém jazyce

Microwave Applicator for Hyperthermia Treatment on in Vivo Melanoma Model

Popis výsledku anglicky

This work evaluates a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in the tumor-bearing animals. The study was firstly performed by simulations of SAR distribution inside a homogeneous phantom, considering an integrated water bolus. Further tests were performed on homogeneous agar phantomto simulate the temperature distribution in the biological tissue and to assess the possible modality and schedule of hyperthermia delivery. The in vivo experiments showed the evidence of microwave-induced heating and damage of the melanoma tissue in arange of penetration coherent both with simulations and phantom studies. This approach appears perspective for designing limited microwave-delivery applicators for treatments of human superficial tumors and pre-tumoral les

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical and Biological Engineering and Computing

ISSN

0140-0118

e-ISSN

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Svazek periodika

48

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000275135300009

EID výsledku v databázi Scopus

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