Abnormalities in Subcortical Motor Preparation in Patients with Idiopathic Cervical Dystonia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F11%3A00203682" target="_blank" >RIV/68407700:21230/11:00203682 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Abnormalities in Subcortical Motor Preparation in Patients with Idiopathic Cervical Dystonia

Popis výsledku v původním jazyce

In patients with cervical dystonia (CD), bradykinesia (slowness of movement) may co-exist with hyperkinesia. The pathophysiological mechanisms of bradykinesia in dystonia are incompletely understood. Our hypothesis is that, because of abnormalities in the integration of sensory inputs, patients with focal dystonia may not reach the adequate level of subcortical motor excitability that would lead to execution of the intended movement at the desired speed. Our aim therefore was to study preparation of subcortical motor circuits for task execution and neurophysiological measures of bradykinesia in patients with cervical dystonia (CD) by means of the so-called StartReact (SR) method. In this method, a startling auditory stimulus (SAS) is applied together with the imperative signal in a reaction time task paradigm. This causes faster movement execution of the prepared motor program.

Název v anglickém jazyce

Abnormalities in Subcortical Motor Preparation in Patients with Idiopathic Cervical Dystonia

Popis výsledku anglicky

In patients with cervical dystonia (CD), bradykinesia (slowness of movement) may co-exist with hyperkinesia. The pathophysiological mechanisms of bradykinesia in dystonia are incompletely understood. Our hypothesis is that, because of abnormalities in the integration of sensory inputs, patients with focal dystonia may not reach the adequate level of subcortical motor excitability that would lead to execution of the intended movement at the desired speed. Our aim therefore was to study preparation of subcortical motor circuits for task execution and neurophysiological measures of bradykinesia in patients with cervical dystonia (CD) by means of the so-called StartReact (SR) method. In this method, a startling auditory stimulus (SAS) is applied together with the imperative signal in a reaction time task paradigm. This causes faster movement execution of the prepared motor program.

Druh

O - Ostatní výsledky

CEP obor

JC - Počítačový hardware a software

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů