Multiple-Input Cultivation Model Based Optimization of Penicillin Production

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F12%3A00198794" target="_blank" >RIV/68407700:21230/12:00198794 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1109/CDC.2012.6426276" target="_blank" >http://dx.doi.org/10.1109/CDC.2012.6426276</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/CDC.2012.6426276" target="_blank" >10.1109/CDC.2012.6426276</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multiple-Input Cultivation Model Based Optimization of Penicillin Production

Popis výsledku v původním jazyce

Unlike prevailing contemporary approach considering the influx feed flow as the only crucial input influencing the final product concentration in bioprocess cultivation, the current paper considers other (non-nutritional) inputs as well. Among them, the volume withdrawal is an important option. Two types of control strategies employing this second input are considered here, each of them using it in a different way. First, the so-called quasi-double-input strategies exploit the broth withdrawal to follow a pre-determined volume profile. Second, the true-double-input strategies consider the second input as a completely independent optimization variable. Main analysis tool here is the gradient optimization numerical algorithm and its adaptations. All resulting strategies are summarized and formulated in the context of optimization, those introduced earlier (i.e., the quasi-double-input) are unified into a common general strategy. Practical complication (inadmissible volume decrease) related to withdrawal introduction is successfully addressed and the summary results show indisputable improvement gained by the non-nutrient input introduction.

Název v anglickém jazyce

Multiple-Input Cultivation Model Based Optimization of Penicillin Production

Popis výsledku anglicky

Unlike prevailing contemporary approach considering the influx feed flow as the only crucial input influencing the final product concentration in bioprocess cultivation, the current paper considers other (non-nutritional) inputs as well. Among them, the volume withdrawal is an important option. Two types of control strategies employing this second input are considered here, each of them using it in a different way. First, the so-called quasi-double-input strategies exploit the broth withdrawal to follow a pre-determined volume profile. Second, the true-double-input strategies consider the second input as a completely independent optimization variable. Main analysis tool here is the gradient optimization numerical algorithm and its adaptations. All resulting strategies are summarized and formulated in the context of optimization, those introduced earlier (i.e., the quasi-double-input) are unified into a common general strategy. Practical complication (inadmissible volume decrease) related to withdrawal introduction is successfully addressed and the summary results show indisputable improvement gained by the non-nutrient input introduction.

Druh

D - Stať ve sborníku

CEP obor

BC - Teorie a systémy řízení

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP103%2F12%2F1794" target="_blank" >GAP103/12/1794: Pokročilé metody pro analýzu a řízení složitých systémů.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 51st IEEE Conference on Decision and Control

ISBN

978-1-4673-2066-5

ISSN

0191-2216

e-ISSN

—

Počet stran výsledku

6

Strana od-do

7075-7080

Název nakladatele

IEEE

Místo vydání

Piscataway

Místo konání akce

Wailea, Maui, Hawaii

Datum konání akce

10. 12. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000327200407054