Grunting in a Genetically Modified Minipig Animal Model for Huntington?s Disease ? a Pilot Experiments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00233967" target="_blank" >RIV/68407700:21230/15:00233967 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.csnn.eu/ceska-slovenska-neurologie-archiv-cisel" target="_blank" >http://www.csnn.eu/ceska-slovenska-neurologie-archiv-cisel</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Grunting in a Genetically Modified Minipig Animal Model for Huntington?s Disease ? a Pilot Experiments

Popis výsledku v původním jazyce

Huntington?s disease (HD) is an autosomal-dominant neurodegenerative disorder characterized by the impairment of voluntary and involuntary movements, behavioral disorders and cognitive decline. Besides the main motor symptoms, voice and speech disordershave been documented in a large majority of patients with HD. The animal model of pigs is often used in preclinical studies. Although there are obvious differences in the anatomy of the articulation organs between pigs and humans, the same trends in pathophysiological mechanisms can be expected in both grunting and human phonation. The main aim of the study was therefore to design a suitable experiment that would allow for acquisition of a sufficiently long recording of grunting from as many pigs as possible. The second goal was to perform the final version of the experiment in all available pigs and to evaluate the amount and quality of the acquired recordings. The database consists of 17 HD transgenic minipigs and 16 healthy siblings.

Název v anglickém jazyce

Grunting in a Genetically Modified Minipig Animal Model for Huntington?s Disease ? a Pilot Experiments

Popis výsledku anglicky

Huntington?s disease (HD) is an autosomal-dominant neurodegenerative disorder characterized by the impairment of voluntary and involuntary movements, behavioral disorders and cognitive decline. Besides the main motor symptoms, voice and speech disordershave been documented in a large majority of patients with HD. The animal model of pigs is often used in preclinical studies. Although there are obvious differences in the anatomy of the articulation organs between pigs and humans, the same trends in pathophysiological mechanisms can be expected in both grunting and human phonation. The main aim of the study was therefore to design a suitable experiment that would allow for acquisition of a sufficiently long recording of grunting from as many pigs as possible. The second goal was to perform the final version of the experiment in all available pigs and to evaluate the amount and quality of the acquired recordings. The database consists of 17 HD transgenic minipigs and 16 healthy siblings.

Druh

D - Stať ve sborníku

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

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Projekt

<a href="/cs/project/GAP102%2F12%2F2230" target="_blank" >GAP102/12/2230: Analýza hlasu a řeči pacientů s onemocněními centrální nervové soustavy</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

The 3rd Conference on Animal Models for Neurodegenerative Diseases - proceedings book

ISBN

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ISSN

1210-7859

e-ISSN

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Počet stran výsledku

5

Strana od-do

"2S61"-"2S65"

Název nakladatele

ČLS JEP

Místo vydání

Praha

Místo konání akce

Liblice

Datum konání akce

8. 11. 2015

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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