Does Extension of Acute BBB Impairment After Stroke Predict Development of VascularEpilepsy?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F18%3A00325745" target="_blank" >RIV/68407700:21230/18:00325745 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Does Extension of Acute BBB Impairment After Stroke Predict Development of VascularEpilepsy?

Popis výsledku v původním jazyce

Purpose:Approximately 5–9% of patients after cerebralstroke develop epilepsy. A precise mechanism of postis-chemic epileptogenesis is not known, however there areseveral currently studied candidates e.g. blood-brain barrier(BBB) defect after ischemia. A reliable biomarker ofpostischemic epilepsy development is needed for properadjustment of postischemic treatment. Aim of this study isto parametrise ischemic lesion and severity of BBB impair-ment in patients after stroke with focus on identification ofparameters candidating as epilepsy biomarker.Method:Five from 150 patients after cerebral ischemiadeveloped epilepsy. 50 patients without and 5 patients withdeveloped epilepsy were randomly selected for furtheranalysis. MRI was measured to all patients 7–12 days afterstroke. MR images were analysed by in-house tailoredalgorithms. Fot detection and parametrization of ischemicregions were used FLAIR (penumbra) and DWI (core)sequences. For detection of BBB impairment after ischemiawere used T1 sequences with and without gadolinium con-trast agent, where gadolinium extravasation was measured.Results:Spatial parameters as volume, overlaps of regionsand location of ischemic lesion, and parameters describingseverity and size of BBB impairment were calculated.Patients which developed epilepsy were compared withthose who did not. Three parameters were significantly dif-ferent between epileptic and nonepileptic patients. Patientsdeveloping epilepsy have larger ischemic regions(p = 0.05) with larger BBB disruption (p = 0.001) andbigger part of BBB impairment was localized outsideischemic regions (p = 0.05) than patients without devel-oped epilepsy...

Název v anglickém jazyce

Does Extension of Acute BBB Impairment After Stroke Predict Development of VascularEpilepsy?

Popis výsledku anglicky

Purpose:Approximately 5–9% of patients after cerebralstroke develop epilepsy. A precise mechanism of postis-chemic epileptogenesis is not known, however there areseveral currently studied candidates e.g. blood-brain barrier(BBB) defect after ischemia. A reliable biomarker ofpostischemic epilepsy development is needed for properadjustment of postischemic treatment. Aim of this study isto parametrise ischemic lesion and severity of BBB impair-ment in patients after stroke with focus on identification ofparameters candidating as epilepsy biomarker.Method:Five from 150 patients after cerebral ischemiadeveloped epilepsy. 50 patients without and 5 patients withdeveloped epilepsy were randomly selected for furtheranalysis. MRI was measured to all patients 7–12 days afterstroke. MR images were analysed by in-house tailoredalgorithms. Fot detection and parametrization of ischemicregions were used FLAIR (penumbra) and DWI (core)sequences. For detection of BBB impairment after ischemiawere used T1 sequences with and without gadolinium con-trast agent, where gadolinium extravasation was measured.Results:Spatial parameters as volume, overlaps of regionsand location of ischemic lesion, and parameters describingseverity and size of BBB impairment were calculated.Patients which developed epilepsy were compared withthose who did not. Three parameters were significantly dif-ferent between epileptic and nonepileptic patients. Patientsdeveloping epilepsy have larger ischemic regions(p = 0.05) with larger BBB disruption (p = 0.001) andbigger part of BBB impairment was localized outsideischemic regions (p = 0.05) than patients without devel-oped epilepsy...

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů