Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F20%3A00341923" target="_blank" >RIV/68407700:21230/20:00341923 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1183/23120541.00146-2020" target="_blank" >https://doi.org/10.1183/23120541.00146-2020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00146-2020" target="_blank" >10.1183/23120541.00146-2020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

Popis výsledku v původním jazyce

Background: Percutaneous microwave ablation is clinically used for inoperable lung tumor treatment. Delivery of microwave ablation applicators to tumor sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax providing a minimally-invasive treatment of early-stage tumors, which are increasingly detected with CT screening. Objectives: The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically-established virtual bronchoscopy guidance system, and assess technical feasibility for safely creating localized thermal ablations in porcine lungs in vivo. Methods: Pre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy guided microwave ablation procedures were performed with 24–32 W power (at the applicator distal tip) delivered for 5–10 mins. A total of 8 ablations were performed in 3 pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis. Results: The flexible microwave applicators were delivered to ablation sites within lung parenchyma 5–24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding were observed. The ablation short axis observed on gross pathology ranged between 16.5–23.5 mm and 14–26 mm on CT imaging. Conclusion: We have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.

Název v anglickém jazyce

Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

Popis výsledku anglicky

Background: Percutaneous microwave ablation is clinically used for inoperable lung tumor treatment. Delivery of microwave ablation applicators to tumor sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax providing a minimally-invasive treatment of early-stage tumors, which are increasingly detected with CT screening. Objectives: The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically-established virtual bronchoscopy guidance system, and assess technical feasibility for safely creating localized thermal ablations in porcine lungs in vivo. Methods: Pre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy guided microwave ablation procedures were performed with 24–32 W power (at the applicator distal tip) delivered for 5–10 mins. A total of 8 ablations were performed in 3 pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis. Results: The flexible microwave applicators were delivered to ablation sites within lung parenchyma 5–24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding were observed. The ablation short axis observed on gross pathology ranged between 16.5–23.5 mm and 14–26 mm on CT imaging. Conclusion: We have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Výzkumné centrum informatiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Respiratory Journal Open Research

ISSN

2312-0541

e-ISSN

2312-0541

Svazek periodika

6

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000603682700025

EID výsledku v databázi Scopus

—