Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F21%3A00357379" target="_blank" >RIV/68407700:21230/21:00357379 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1088/2057-1976/ac27c2" target="_blank" >https://doi.org/10.1088/2057-1976/ac27c2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/2057-1976/ac27c2" target="_blank" >10.1088/2057-1976/ac27c2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies

Popis výsledku v původním jazyce

Microwave ablation is under investigation as a minimally-invasive treatment for uterine fibroids. Computational models play a vital role in the development, evaluation and characterization of candidate ablation devices. The temperature-dependent dielectric properties of fibroid tissue are essential for accurate computational modeling. Objective: To measure the broadband temperaturedependent dielectric properties of uterine fibroids excised during hysterectomy procedures. Methods: The open-ended coaxial probe method was employed for measuring the broadband dielectric properties of freshly excised human uterine fibroid samples (n=6) obtained from an IRB-approved tissue bank. The dielectric properties (relative permittivity, εr, and effective electrical conductivity,σeff) were evaluated at temperatures ranging from 23 °C–150 °C, over the frequency range of 0.5–6 GHz. Linear piecewise parametrization with respect to temperature and quadratic parametrization with respect to frequency was applied to characterize broadband temperature-dependent dielectric properties of fibroid tissue. Results: The baseline room temperature values of εr vary from 57.5±5.29 to 44.5±5.77 units and σeff changes from 0.91±0.19 to 6.02±0.7 Sm-1 over the frequency range of 0.5–6 GHz. At temperatures close to the water vaporization point, εr, drops considerably i.e. to 12%–14% of its baseline value for all measured frequencies. σeff values initially rise till 98 °C and then fall to 11%–13% of their baseline values at 125 °C for frequencies„2.45 GHz. The σeff follows a decreasing trend for frequencies>2.45 GHz and drops to~6%of their baseline room temperature values. Conclusion: The temperature dependent dielectric properties of uterine fibroid tissues over microwave frequency range are reported for the first time in this study. Parametric models of uterine fibroid dielectric properties are also presented for incorporation within computational models of microwave ablation of fibroids.

Název v anglickém jazyce

Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies

Popis výsledku anglicky

Microwave ablation is under investigation as a minimally-invasive treatment for uterine fibroids. Computational models play a vital role in the development, evaluation and characterization of candidate ablation devices. The temperature-dependent dielectric properties of fibroid tissue are essential for accurate computational modeling. Objective: To measure the broadband temperaturedependent dielectric properties of uterine fibroids excised during hysterectomy procedures. Methods: The open-ended coaxial probe method was employed for measuring the broadband dielectric properties of freshly excised human uterine fibroid samples (n=6) obtained from an IRB-approved tissue bank. The dielectric properties (relative permittivity, εr, and effective electrical conductivity,σeff) were evaluated at temperatures ranging from 23 °C–150 °C, over the frequency range of 0.5–6 GHz. Linear piecewise parametrization with respect to temperature and quadratic parametrization with respect to frequency was applied to characterize broadband temperature-dependent dielectric properties of fibroid tissue. Results: The baseline room temperature values of εr vary from 57.5±5.29 to 44.5±5.77 units and σeff changes from 0.91±0.19 to 6.02±0.7 Sm-1 over the frequency range of 0.5–6 GHz. At temperatures close to the water vaporization point, εr, drops considerably i.e. to 12%–14% of its baseline value for all measured frequencies. σeff values initially rise till 98 °C and then fall to 11%–13% of their baseline values at 125 °C for frequencies„2.45 GHz. The σeff follows a decreasing trend for frequencies>2.45 GHz and drops to~6%of their baseline room temperature values. Conclusion: The temperature dependent dielectric properties of uterine fibroid tissues over microwave frequency range are reported for the first time in this study. Parametric models of uterine fibroid dielectric properties are also presented for incorporation within computational models of microwave ablation of fibroids.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Výzkumné centrum informatiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Physics & Engineering Express

ISSN

2057-1976

e-ISSN

2057-1976

Svazek periodika

7

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000711650900001

EID výsledku v databázi Scopus

2-s2.0-85119056948