Distributed brain co-processor for tracking spikes, seizures and behavior during electrical brain stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F22%3A00357965" target="_blank" >RIV/68407700:21230/22:00357965 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/22:00357965 RIV/68407700:21730/22:00357965

Výsledek na webu

<a href="https://doi.org/10.1093/braincomms/fcac115" target="_blank" >https://doi.org/10.1093/braincomms/fcac115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/braincomms/fcac115" target="_blank" >10.1093/braincomms/fcac115</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distributed brain co-processor for tracking spikes, seizures and behavior during electrical brain stimulation

Popis výsledku v původním jazyce

Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioral inputs from patients. Recent epilepsy stimulation devices provide brain sensing but have not yet developed analytics for accurately tracking and quantifying behavior and seizures. Here we describe a distributed brain co-processor providing an intuitive bi-directional interface between patient, implanted neural stimulation and sensing device, and local and distributed computing resources. Automated analysis of continuous streaming electrophysiology is synchronized with patient reports using a hand-held device and integrated with distributed cloud computing resources for quantifying seizures, interictal epileptiform spikes, and patient symptoms during therapeutic electrical brain stimulation. The classification algorithms for interictal epileptiform spikes and seizures were developed and parameterized using long-term ambulatory data from 9 humans and 8 canines with epilepsy, and then implemented prospectively in out-of-sample testing in 2 pet canines and 4 humans with drug resistant epilepsy living in their natural environments. Accurate seizure diaries are needed as the primary clinical outcome measure of epilepsy therapy and to guide brain stimulation optimization. The brain co-processor system described here enables tracking interictal epileptiform spikes, seizures, and correlation with patient behavioral reports. In the future correlation of spikes and seizures with behavior will allow more detailed investigation of the clinical impact of spikes and seizures on patients.

Název v anglickém jazyce

Distributed brain co-processor for tracking spikes, seizures and behavior during electrical brain stimulation

Popis výsledku anglicky

Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioral inputs from patients. Recent epilepsy stimulation devices provide brain sensing but have not yet developed analytics for accurately tracking and quantifying behavior and seizures. Here we describe a distributed brain co-processor providing an intuitive bi-directional interface between patient, implanted neural stimulation and sensing device, and local and distributed computing resources. Automated analysis of continuous streaming electrophysiology is synchronized with patient reports using a hand-held device and integrated with distributed cloud computing resources for quantifying seizures, interictal epileptiform spikes, and patient symptoms during therapeutic electrical brain stimulation. The classification algorithms for interictal epileptiform spikes and seizures were developed and parameterized using long-term ambulatory data from 9 humans and 8 canines with epilepsy, and then implemented prospectively in out-of-sample testing in 2 pet canines and 4 humans with drug resistant epilepsy living in their natural environments. Accurate seizure diaries are needed as the primary clinical outcome measure of epilepsy therapy and to guide brain stimulation optimization. The brain co-processor system described here enables tracking interictal epileptiform spikes, seizures, and correlation with patient behavioral reports. In the future correlation of spikes and seizures with behavior will allow more detailed investigation of the clinical impact of spikes and seizures on patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Communications

ISSN

2632-1297

e-ISSN

2632-1297

Svazek periodika

4

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

1-16

Kód UT WoS článku

000814811600002

EID výsledku v databázi Scopus

2-s2.0-85136094010