Integrated Digital System for Long-Term Behavioral Tracking and Adaptive Electrical Brain Stimulation in Humans with Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU144334" target="_blank" >RIV/00216305:26220/21:PU144334 - isvavai.cz</a>

Výsledek na webu

<a href="https://cms.aesnet.org/abstractslisting/automated-sleep-classification-and-brain-stimulation-with-implantable-devices" target="_blank" >https://cms.aesnet.org/abstractslisting/automated-sleep-classification-and-brain-stimulation-with-implantable-devices</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Integrated Digital System for Long-Term Behavioral Tracking and Adaptive Electrical Brain Stimulation in Humans with Epilepsy

Popis výsledku v původním jazyce

Rationale: Electrical stimulation of the brain (ESB) is used in FDA-approved approaches for patients with drug resistant epilepsy (DRE), but current neuromodulatory approaches are largely palliative, difficult to optimize, and do not target psychiatric or cognitive comorbidities. We developed and implemented a digital health system for long-term tracking of interictal epileptiform activity, seizures, behavior, cognition, and mood comorbidities to improve the management of patients with DRE by streaming data from implanted and wearable devices, patient reported measures of sleep, cognition, and mood. Real-time analytics provides accurate seizure diaries, interictal epileptiform spike rates, dense behavioral tracking, and automated patient specific adaptive stimulation. Methods: Pre-clinical testing was completed in 13 pet and research canines with epilepsy implanted with the investigational Medtronic Summit RC+STM system (bilateral hippocampus & anterior nucleus of the thalamus), with wireless connect

Název v anglickém jazyce

Integrated Digital System for Long-Term Behavioral Tracking and Adaptive Electrical Brain Stimulation in Humans with Epilepsy

Popis výsledku anglicky

Rationale: Electrical stimulation of the brain (ESB) is used in FDA-approved approaches for patients with drug resistant epilepsy (DRE), but current neuromodulatory approaches are largely palliative, difficult to optimize, and do not target psychiatric or cognitive comorbidities. We developed and implemented a digital health system for long-term tracking of interictal epileptiform activity, seizures, behavior, cognition, and mood comorbidities to improve the management of patients with DRE by streaming data from implanted and wearable devices, patient reported measures of sleep, cognition, and mood. Real-time analytics provides accurate seizure diaries, interictal epileptiform spike rates, dense behavioral tracking, and automated patient specific adaptive stimulation. Methods: Pre-clinical testing was completed in 13 pet and research canines with epilepsy implanted with the investigational Medtronic Summit RC+STM system (bilateral hippocampus & anterior nucleus of the thalamus), with wireless connect

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů