Integrated Digital System for Dense Behavioral Tracking and Adaptive Electrical Brain Stimulation: Canines and Humans with Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F20%3APU138069" target="_blank" >RIV/00216305:26220/20:PU138069 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Integrated Digital System for Dense Behavioral Tracking and Adaptive Electrical Brain Stimulation: Canines and Humans with Epilepsy

Popis výsledku v původním jazyce

Rationale: Electrical stimulation of the brain (ESB) is an emerging therapy for diseases of the brain and mind. Although ESB is FDA approved for patients with drug resistant epilepsy (DRE), current neuromodulatory approaches are largely palliative and do not target psychiatric or cognitive comorbidities. We have developed a digital health system that should accelerate treatment optimization for DRE. The system enables management of patients by streaming physiological data from implanted and wearable devices coupled with direct queries to the patient triggered by system analytics and scheduled queries for measures of sleep quality, cognition, and mood. Real-time analytics of physiological data streams provide accurate seizure diaries, dense behavioral tracking and patient interactions, and automated patient specific adaptive stimulation. Methods: Initial pre-clinical work has been performed in canines with epilepsy implanted with the investigational Medtronic Summit RC+S (TM) system (sense and stimula

Název v anglickém jazyce

Integrated Digital System for Dense Behavioral Tracking and Adaptive Electrical Brain Stimulation: Canines and Humans with Epilepsy

Popis výsledku anglicky

Rationale: Electrical stimulation of the brain (ESB) is an emerging therapy for diseases of the brain and mind. Although ESB is FDA approved for patients with drug resistant epilepsy (DRE), current neuromodulatory approaches are largely palliative and do not target psychiatric or cognitive comorbidities. We have developed a digital health system that should accelerate treatment optimization for DRE. The system enables management of patients by streaming physiological data from implanted and wearable devices coupled with direct queries to the patient triggered by system analytics and scheduled queries for measures of sleep quality, cognition, and mood. Real-time analytics of physiological data streams provide accurate seizure diaries, dense behavioral tracking and patient interactions, and automated patient specific adaptive stimulation. Methods: Initial pre-clinical work has been performed in canines with epilepsy implanted with the investigational Medtronic Summit RC+S (TM) system (sense and stimula

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů