Distinct patterns of interictal intracranial EEG in focal cortical dysplasia type I and II

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F23%3A00364919" target="_blank" >RIV/68407700:21230/23:00364919 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/23:10462217 RIV/00216208:11130/23:10462217

Výsledek na webu

<a href="https://doi.org/10.1016/j.clinph.2023.03.360" target="_blank" >https://doi.org/10.1016/j.clinph.2023.03.360</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2023.03.360" target="_blank" >10.1016/j.clinph.2023.03.360</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct patterns of interictal intracranial EEG in focal cortical dysplasia type I and II

Popis výsledku v původním jazyce

Objective: Focal cortical dysplasia (FCD) is the most common malformation causing refractory focal epilepsy. Surgical removal of the entire dysplastic cortex is crucial for achieving a seizure-free outcome. Precise presurgical distinctions between FCD types by neuroimaging are difficult, mainly in patients with normal magnetic resonance imaging findings. However, the FCD type is important for planning the extent of surgical approach and counselling. Methods: This study included patients with focal drug-resistant epilepsy and definite histopathological FCD type I or II diagnoses who underwent intracranial electroencephalography (iEEG). We detected interictal epileptiform discharges (IEDs) and their recruitment into repetitive discharges (RDs) to compare electrophysiological patterns characterizing FCD types. Results: Patients with FCD type II had a significantly higher IED rate (p<0.005), a shorter inter-discharge interval within RD episodes (p<0.003), sleep influence on decreased RD periodicity (p<0.036), and longer RD episode duration (p<0.003) than patients with type I. A Bayesian classifier stratified FCD types with 82% accuracy. Conclusion: Temporal characteristics of IEDs and RDs reflect the histological findings of FCD subtypes and can differentiate FCD types I and II. Significance: Presurgical prediction of FCD type can help to plan a more tailored surgical approach in patients with normal magnetic resonance findings.

Název v anglickém jazyce

Distinct patterns of interictal intracranial EEG in focal cortical dysplasia type I and II

Popis výsledku anglicky

Objective: Focal cortical dysplasia (FCD) is the most common malformation causing refractory focal epilepsy. Surgical removal of the entire dysplastic cortex is crucial for achieving a seizure-free outcome. Precise presurgical distinctions between FCD types by neuroimaging are difficult, mainly in patients with normal magnetic resonance imaging findings. However, the FCD type is important for planning the extent of surgical approach and counselling. Methods: This study included patients with focal drug-resistant epilepsy and definite histopathological FCD type I or II diagnoses who underwent intracranial electroencephalography (iEEG). We detected interictal epileptiform discharges (IEDs) and their recruitment into repetitive discharges (RDs) to compare electrophysiological patterns characterizing FCD types. Results: Patients with FCD type II had a significantly higher IED rate (p<0.005), a shorter inter-discharge interval within RD episodes (p<0.003), sleep influence on decreased RD periodicity (p<0.036), and longer RD episode duration (p<0.003) than patients with type I. A Bayesian classifier stratified FCD types with 82% accuracy. Conclusion: Temporal characteristics of IEDs and RDs reflect the histological findings of FCD subtypes and can differentiate FCD types I and II. Significance: Presurgical prediction of FCD type can help to plan a more tailored surgical approach in patients with normal magnetic resonance findings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

151

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

10-17

Kód UT WoS článku

000991291400001

EID výsledku v databázi Scopus

2-s2.0-85153800585